Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T34867 Target Info
Target Name Poly [ADP-ribose] polymerase (PARP)
Synonyms
Poly-ADP-ribose polymerase
    Click to Show/Hide
Target Type Successful Target
Gene Name NO-GeName
UniProt ID
NOUNIPROTAC
Co-Targets of This Target  Top
Co-Target Name Tankyrase-2 (TNKS-2) Patented-recorded Target
UniProt ID TNKS2_HUMAN
Gene Name TNKS2
Synonyms
Tankyrase-related protein; Tankyrase-like protein; Tankyrase II; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; TNKL; TANK2; Protein poly-ADP-ribosyltransferase tankyrase-2; Poly [ADP-ribose] polymerase tankyrase-2; Poly [ADP-ribose] polymerase 5B; PARP5B; ARTD6; ADP-ribosyltransferase diphtheria toxin-like 6
    Click to Show/Hide
Representative Drug(s) Rucaparib Drug Info IC50 = 14 nM [1]
Co-Target Name Tankyrase-1 (TNKS-1) Patented-recorded Target
UniProt ID TNKS1_HUMAN
Gene Name TNKS
Synonyms
Tankyrase I; TRF1-interacting ankyrin-related ADP-ribose polymerase; TNKS1; TINF1; TIN1; TANK1; Protein poly-ADP-ribosyltransferase tankyrase-1; Poly [ADP-ribose] polymerase tankyrase-1; Poly [ADP-ribose] polymerase 5A; PARPL; PARP5A; ARTD5; ADP-ribosyltransferase diphtheria toxin-like 5
    Click to Show/Hide
Representative Drug(s) Rucaparib Drug Info IC50 = 25 nM Click to Show More [1]
2 MK-4827 Drug Info IC50 = 570 nM [2]
References  Top
REF 1 Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Med Chem Lett. 2013 Nov 20;5(1):18-22.
REF 2 Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.