Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T34949 Target Info
Target Name Voltage-gated calcium channel alpha Cav2.1 (CACNA1A)
Synonyms
Voltage-gated calcium channel alpha subunit Cav2.1; Voltage-dependent P/Q-type calcium channel; RBA-I; RAT brain class A; Calcium channel, L type, alpha-1 polypeptide, isoform 4; Calcium channel, L type, alpha-1 polypeptide isoform 4; CACNA1A; Brain calcium channel I; BI
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Target Type Successful Target
Gene Name CACNA1A
Biochemical Class Voltage-gated ion channel
UniProt ID
CAC1A_HUMAN
Co-Targets of This Target  Top
Co-Target Name Cytochrome P450 2J2 (CYP2J2) Co-Target
UniProt ID CP2J2_HUMAN
Gene Name CYP2J2
Synonyms
Albendazole monooxygenase (hydroxylating); Albendazole monooxygenase (sulfoxide-forming); Arachidonic acid epoxygenase; Hydroperoxy icosatetraenoate isomerase; CYPIIJ2
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Representative Drug(s) Flunarizine Drug Info Ki = 100 nM [1]
Co-Target Name Brain sodium channel alpha (Types I, II, III) Co-Target
UniProt ID SCN1A_HUMAN; SCN2A_HUMAN; SCN3A_HUMAN
Gene Name SCN1A; SCN2A; SCN3A
Representative Drug(s) Flunarizine Drug Info IC50 = 600 nM [2]
References  Top
REF 1 Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug Metab Dispos. 2013 Jan;41(1):60-71.
REF 2 [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. J Med Chem. 1985 Mar;28(3):381-8.

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