Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T37848 | Target Info | |||
| Target Name | Albendazole monooxygenase (CYP3A4) | ||||
| Synonyms |
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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| Target Type | Clinical trial Target | ||||
| Gene Name | CYP3A4 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Melanocortin receptor 4 (MC4R) | Successful Target | ||||
| UniProt ID | MC4R_HUMAN | |||||
| Gene Name | MC4R | |||||
| Synonyms |
MC4-R
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 400 nM | [1] | ||
| Co-Target Name | Amyloid beta A4 protein (APP) | Successful Target | ||||
| UniProt ID | A4_HUMAN | |||||
| Gene Name | APP | |||||
| Synonyms |
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
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| Representative Drug(s) | Curcumin | Drug Info | IC50 = 630 nM | [2] | ||
| Co-Target Name | Monoamine oxidase type A (MAO-A) | Successful Target | ||||
| UniProt ID | AOFA_HUMAN | |||||
| Gene Name | MAOA | |||||
| Synonyms |
Monoamine oxidase A; Amine oxidase [flavin-containing] A
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| Representative Drug(s) | Curcumin | Drug Info | Ki = 710 nM | [3] | ||
| Co-Target Name | Vasopressin V1a receptor (V1AR) | Successful Target | ||||
| UniProt ID | V1AR_HUMAN | |||||
| Gene Name | AVPR1A | |||||
| Synonyms |
Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 740 nM | [1] | ||
| Co-Target Name | Lactoylglutathione lyase (GLO1) | Clinical trial Target | ||||
| UniProt ID | LGUL_HUMAN | |||||
| Gene Name | GLO1 | |||||
| Synonyms |
S-D-lactoylglutathione methylglyoxal lyase; Methylglyoxalase; Ketone-aldehyde mutase; Glyoxalase I; GlxI; Glx I; GLO1; Aldoketomutase
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| Representative Drug(s) | Curcumin | Drug Info | Ki = 5 nM | [4] | ||
| Co-Target Name | Tissue factor (F3) | Successful Target | ||||
| UniProt ID | TF_HUMAN | |||||
| Gene Name | F3 | |||||
| Synonyms |
Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen
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| Representative Drug(s) | Curcumin | Drug Info | IC50 = 13.16 nM | [5] | ||
| Co-Target Name | C5a anaphylatoxin chemotactic receptor (C5AR1) | Successful Target | ||||
| UniProt ID | C5AR1_HUMAN | |||||
| Gene Name | C5AR1 | |||||
| Synonyms |
CD88; C5aR; C5a-R; C5a anaphylatoxin chemotactic receptor 1; C5R1
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 15 nM | [6] | ||
| Co-Target Name | Substance-K receptor (TACR2) | Clinical trial Target | ||||
| UniProt ID | NK2R_HUMAN | |||||
| Gene Name | TACR2 | |||||
| Synonyms |
Tachykinin receptor 2; Tachykinin neurokinin 2 receptor; TACR2; SKR; Neurokinin A receptor; NK-2R; NK-2 receptor
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| Representative Drug(s) | PMX-53 | Drug Info | IC50 = 87 nM | [1] | ||
| Co-Target Name | Prostaglandin E synthase (PTGES) | Clinical trial Target | ||||
| UniProt ID | PTGES_HUMAN | |||||
| Gene Name | PTGES | |||||
| Synonyms |
p53-induced gene 12 protein; PIG12; PGES; PGE synthase; P53-induced apoptosis protein 12; Microsomal prostaglandin E synthase 1; Microsomal glutathione S-transferase 1-like 1; MPGES1; MPGES-1; MGST1L1; MGST1-L1
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| Representative Drug(s) | Curcumin | Drug Info | IC50 = 200 nM | [7] | ||
| Co-Target Name | CDGSH iron-sulfur domain-containing protein 1 (CISD1_HUMAN) | Co-Target | ||||
| UniProt ID | CISD1_HUMAN | |||||
| Gene Name | CISD1 | |||||
| Synonyms |
MitoNEET
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| Representative Drug(s) | Curcumin | Drug Info | Ki = 101 nM | [8] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. | ||||
| REF 2 | Neuritogenic activity of bi-functional bis-tryptoline triazole. Bioorg Med Chem. 2017 Feb 1;25(3):1195-1201. | ||||
| REF 3 | Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis. ACS Med Chem Lett. 2015 Dec 1;7(1):56-61. | ||||
| REF 4 | Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243. | ||||
| REF 5 | Microbial hydroxylation and glycosylation of pentacyclic triterpenes as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1026-30. | ||||
| REF 6 | Selective hexapeptide agonists and antagonists for human complement C3a receptor. J Med Chem. 2010 Jul 8;53(13):4938-48. | ||||
| REF 7 | Targeting microsomal prostaglandin E2 synthase-1 (mPGES-1): the development of inhibitors as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs). Medchemcomm. 2015;6:2081-123. | ||||
| REF 8 | Identification of small molecules that bind to the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5350-5353. | ||||
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