Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T41580 | Target Info | |||
| Target Name | Adrenergic receptor alpha-2B (ADRA2B) | ||||
| Synonyms |
Subtype C2; Alpha-2BAR; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptor subtype C2; ADRA2RL1; ADRA2L1
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| Target Type | Successful Target | ||||
| Gene Name | ADRA2B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Adrenergic receptor alpha-2A (ADRA2A) | Successful Target | ||||
| UniProt ID | ADA2A_HUMAN | |||||
| Gene Name | ADRA2A | |||||
| Synonyms |
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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| Representative Drug(s) | MOXONIDINE | Drug Info | Ki = 150 nM | [1] | ||
| Co-Target Name | Imidazoline receptor 1 (IR1) | Literature-reported Target | ||||
| UniProt ID | NISCH_HUMAN | |||||
| Gene Name | NISCH | |||||
| Synonyms |
hIRAS; KIAA0975; Imidazoline-1 receptor candidate protein; Imidazoline-1 receptor; Imidazoline receptor antisera-selected protein; IRAS; IR1; I1R candidate protein; I-1 receptor candidate protein; I-1
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| Representative Drug(s) | MOXONIDINE | Drug Info | IC50 = 3.548 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J Med Chem. 1996 Mar 15;39(6):1193-5. | ||||
| REF 2 | Bicyclic alpha-Iminophosphonates as High Affinity Imidazoline I 2 Receptor Ligands for Alzheimer's Disease. J Med Chem. 2020 Apr 9;63(7):3610-3633. | ||||
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