Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46185 | Target Info | |||
| Target Name | Muscarinic acetylcholine receptor M2 (CHRM2) | ||||
| Synonyms |
M2 receptor; CHRM2
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| Target Type | Successful Target | ||||
| Gene Name | CHRM2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Muscarinic acetylcholine receptor M1 (CHRM1) | Successful Target | ||||
| UniProt ID | ACM1_HUMAN | |||||
| Gene Name | CHRM1 | |||||
| Synonyms |
M1 receptor
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| Representative Drug(s) | Methylscopolamine | Drug Info | Ki = 0.0955 nM | [1] | ||
| Co-Target Name | Muscarinic acetylcholine receptor M3 (CHRM3) | Successful Target | ||||
| UniProt ID | ACM3_HUMAN | |||||
| Gene Name | CHRM3 | |||||
| Synonyms |
M3 receptor; CHRM3
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| Representative Drug(s) | Methylscopolamine | Drug Info | Ki = 0.1349 nM | [2] | ||
| Co-Target Name | Muscarinic acetylcholine receptor M4 (CHRM4) | Successful Target | ||||
| UniProt ID | ACM4_HUMAN | |||||
| Gene Name | CHRM4 | |||||
| Synonyms |
M4 receptor; CHRM4
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| Representative Drug(s) | Methylscopolamine | Drug Info | Ki = 0.1413 nM | [3] | ||
| Co-Target Name | Muscarinic acetylcholine receptor M5 (CHRM5) | Successful Target | ||||
| UniProt ID | ACM5_HUMAN | |||||
| Gene Name | CHRM5 | |||||
| Synonyms |
CHRM5
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| Representative Drug(s) | Methylscopolamine | Drug Info | Ki = 0.2089 nM | [3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors. J Med Chem. 2012 Mar 8;55(5):2125-43. | ||||
| REF 2 | Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure. J Med Chem. 2010 Jan 14;53(1):201-7. | ||||
| REF 3 | Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure. J Med Chem. 2007 Mar 22;50(6):1409-13. | ||||
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