Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T46360 Target Info
Target Name Opioid receptor sigma 1 (OPRS1)
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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Target Type Successful Target
Gene Name SIGMAR1
Biochemical Class GPCR rhodopsin
UniProt ID
SGMR1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Aldose reductase (AKR1B1) Successful Target
UniProt ID ALDR_HUMAN
Gene Name AKR1B1
Synonyms
Aldehyde reductase; AKR1B1
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Representative Drug(s) SSR-125047 Drug Info IC50 = 10 nM [1]
Co-Target Name Aldo-keto reductase family 1 member B10 (AKR1B10) Co-Target
UniProt ID AK1BA_HUMAN
Gene Name AKR1B10
Synonyms
ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase
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Representative Drug(s) SSR-125047 Drug Info IC50 = 11.6 nM [2]
Co-Target Name Aldo-keto reductase family 1 member A1 (AKR1A1) Co-Target
UniProt ID AK1A1_HUMAN
Gene Name AKR1A1
Synonyms
Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase
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Representative Drug(s) SSR-125047 Drug Info IC50 = 720 nM [1]
References  Top
REF 1 Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10. Bioorg Med Chem. 2010 Apr 1;18(7):2485-90.
REF 2 Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9.

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