Co-Targets of This Target |
Top |
Co-Target Name |
Platelet-derived growth factor receptor alpha (PDGFRA) |
Successful Target |
UniProt ID |
PGFRA_HUMAN
|
Gene Name |
PDGFRA
|
Synonyms |
RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGFR2; PDGFR-alpha; PDGFR-2; PDGF-R-alpha; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor |
Representative Drug(s) |
ABT-348 |
Drug Info
|
Ki = 0.7943 nM |
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[1] |
2 |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
Co-Target Name |
Fibroblast growth factor receptor 2 (FGFR2) |
Successful Target |
UniProt ID |
FGFR2_HUMAN
|
Gene Name |
FGFR2
|
Synonyms |
Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; KSAM; KGFR; K-sam; FGFR-2; FGF-2 receptor; CD332; BEK |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
Janus kinase 2 (JAK-2) |
Successful Target |
UniProt ID |
JAK2_HUMAN
|
Gene Name |
JAK2
|
Synonyms |
Tyrosine-protein kinase JAK2 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[3] |
Co-Target Name |
Janus kinase 3 (JAK-3) |
Successful Target |
UniProt ID |
JAK3_HUMAN
|
Gene Name |
JAK3
|
Synonyms |
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[3] |
Co-Target Name |
Proto-oncogene c-Ret (RET) |
Successful Target |
UniProt ID |
RET_HUMAN
|
Gene Name |
RET
|
Synonyms |
RET51; RET receptor tyrosine kinase; RET mutant Y791F; RET mutant V804M; RET mutant V804L; RET mutant S891A; RET mutant M918T; RET mutant G691S; Proto-oncogene tyrosine-protein kinase receptor Ret; PTC; Cadherin family member 12; CDHR16; CDHF12; C-ret |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
Click to Show More |
[2] |
2 |
ABT-348 |
Drug Info
|
IC50 = 7 nM |
[5] |
3 |
PHA-739358 |
Drug Info
|
IC50 = 31 nM |
[9] |
Co-Target Name |
Vascular endothelial growth factor receptor 2 (KDR) |
Successful Target |
UniProt ID |
VGFR2_HUMAN
|
Gene Name |
KDR
|
Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309 |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 2 nM |
Click to Show More |
[4] |
2 |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
3 |
R763 |
Drug Info
|
IC50 = 19 nM |
[4] |
4 |
CYC116 |
Drug Info
|
Ki = 44 nM |
[10] |
5 |
Rosiglitazone + metformin |
Drug Info
|
IC50 = 135 nM |
[14] |
6 |
PHA-739358 |
Drug Info
|
IC50 = 432 nM |
[9] |
Co-Target Name |
LCK tyrosine protein kinase (LCK) |
Successful Target |
UniProt ID |
LCK_HUMAN
|
Gene Name |
LCK
|
Synonyms |
p56-LCK; Tyrosine-protein kinase Lck; T cell-specific protein-tyrosine kinase; Proto-oncogene tyrosine-protein kinase LCK; Proto-oncogene Lck; Protein YT16; Lymphocyte cell-specific protein-tyrosine kinase; Leukocyte C-terminal Src kinase; LSK; LCK p59-Fyn; LCK Protooncogene Syn |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 3 nM |
Click to Show More |
[5] |
2 |
VX-680 |
Drug Info
|
Ki = 80 nM |
[3] |
3 |
PHA-739358 |
Drug Info
|
IC50 = 155 nM |
[9] |
4 |
AZD-1152-HQPA |
Drug Info
|
Ki = 170 nM |
[15] |
Co-Target Name |
Platelet-derived growth factor receptor beta (PDGFRB) |
Successful Target |
UniProt ID |
PGFRB_HUMAN
|
Gene Name |
PDGFRB
|
Synonyms |
Platelet-derived growth factor receptor 1; PDGFR1; PDGFR-beta; PDGFR-1; PDGFR; PDGF-R-beta; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 3 nM |
Click to Show More |
[5] |
2 |
Rosiglitazone + metformin |
Drug Info
|
IC50 = 50 nM |
[11] |
Co-Target Name |
Tyrosine-protein kinase ABL1 (ABL) |
Successful Target |
UniProt ID |
ABL1_HUMAN
|
Gene Name |
ABL1
|
Synonyms |
p150; Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 4 nM |
Click to Show More |
[3] |
2 |
PHA-739358 |
Drug Info
|
IC50 = 5 nM |
[6] |
3 |
ABT-348 |
Drug Info
|
IC50 = 12 nM |
[5] |
4 |
VX-680 |
Drug Info
|
Ki = 30 nM |
[3] |
Co-Target Name |
Fibroblast growth factor receptor 1 (FGFR1) |
Successful Target |
UniProt ID |
FGFR1_HUMAN
|
Gene Name |
FGFR1
|
Synonyms |
c-fgr; bFGF-R-1; bFGF-R; N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT2; FLT-2; FLG; FGFR-1; FGFBR; CEK; CD331 antigen; CD331; Basic fibroblast growth factor receptor 1; BFGFR |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
Click to Show More |
[2] |
2 |
PHA-739358 |
Drug Info
|
IC50 = 47 nM |
[9] |
3 |
GSK1070916 |
Drug Info
|
IC50 = 76 nM |
[13] |
4 |
ABT-348 |
Drug Info
|
IC50 = 188 nM |
[5] |
Co-Target Name |
Fms-like tyrosine kinase 3 (FLT-3) |
Successful Target |
UniProt ID |
FLT3_HUMAN
|
Gene Name |
FLT3
|
Synonyms |
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
Click to Show More |
[2] |
2 |
CYC116 |
Drug Info
|
IC50 = 25.12 nM |
[7] |
3 |
VX-680 |
Drug Info
|
IC50 = 30 nM |
[8] |
4 |
AZD-1152-HQPA |
Drug Info
|
IC50 = 100 nM |
[7] |
5 |
PHA-739358 |
Drug Info
|
IC50 = 669 nM |
[9] |
Co-Target Name |
Proto-oncogene c-Src (SRC) |
Successful Target |
UniProt ID |
SRC_HUMAN
|
Gene Name |
SRC
|
Synonyms |
pp60c-src; Tyrosine kinase (pp60(src)); Src tyrosine kinase; SRC1; Proto-oncogene tyrosine-protein kinase Src; Pp60(src); P60-Src; C-src TK; C-Src |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
Click to Show More |
[2] |
2 |
CYC116 |
Drug Info
|
Ki = 820 nM |
[10] |
Co-Target Name |
Tropomyosin-related kinase A (TrkA) |
Successful Target |
UniProt ID |
NTRK1_HUMAN
|
Gene Name |
NTRK1
|
Synonyms |
gp140trk; Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; Neurotrophic tyrosine kinase receptor type 1; NGF-trk receptor type A; MTC; High affinity nerve growth factor receptor |
Representative Drug(s) |
PHA-739358 |
Drug Info
|
IC50 = 30 nM |
[9] |
Co-Target Name |
Fusion protein Bcr-Abl (Bcr-Abl) |
Successful Target |
UniProt ID |
BCR_HUMAN-ABL1_HUMAN
|
Gene Name |
BCR-ABL1
|
Synonyms |
BCR-ABL fusion protein; BCR-ABL |
Representative Drug(s) |
VX-680 |
Drug Info
|
IC50 = 50.12 nM |
[12] |
Co-Target Name |
Fyn tyrosine protein kinase (FYN) |
Successful Target |
UniProt ID |
FYN_HUMAN
|
Gene Name |
FYN
|
Synonyms |
Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; Fyn p59-Fyn; Fyn Protooncogene Syn |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 110 nM |
[5] |
Co-Target Name |
ALK tyrosine kinase receptor (ALK) |
Successful Target |
UniProt ID |
ALK_HUMAN
|
Gene Name |
ALK
|
Synonyms |
CD246; Anaplastic lymphoma kinase |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 363 nM |
[5] |
Co-Target Name |
Tyrosine-protein kinase Kit (KIT) |
Successful Target |
UniProt ID |
KIT_HUMAN
|
Gene Name |
KIT
|
Synonyms |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; p145 c-kit; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; Mast/stem cell growth factor receptor Kit; CD117 antigen; CD117; C-kit |
Representative Drug(s) |
PHA-739358 |
Drug Info
|
IC50 = 407 nM |
[9] |
Co-Target Name |
Rho-associated protein kinase 1 (ROCK1) |
Successful Target |
UniProt ID |
ROCK1_HUMAN
|
Gene Name |
ROCK1
|
Synonyms |
Rok; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated kinase 1; Rho kinase; ROCK1; ROCK; P160ROCK; P160(rock); P160 ROCK-1; Let-502 kinase |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 456 nM |
[5] |
Co-Target Name |
Insulin-like growth factor I receptor (IGF1R) |
Successful Target |
UniProt ID |
IGF1R_HUMAN
|
Gene Name |
IGF1R
|
Synonyms |
Type 1 insulin-like growth factor receptor; Insulin-like growth factor 1 receptor; IGF-IR; IGF-I receptor; IGF-1R; IGF-1 receptor; CD221 antigen; CD221 |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 539 nM |
[5] |
Co-Target Name |
Voltage-gated potassium channel Kv11.1 (KCNH2) |
Successful Target |
UniProt ID |
KCNH2_HUMAN
|
Gene Name |
KCNH2
|
Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG |
Representative Drug(s) |
ABT-348 |
Drug Info
|
IC50 = 1000 nM |
[5] |
Co-Target Name |
Aurora kinase A (AURKA) |
Clinical trial Target |
UniProt ID |
AURKA_HUMAN
|
Gene Name |
AURKA
|
Synonyms |
hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK |
Representative Drug(s) |
MK-5108 |
Drug Info
|
IC50 = 0.046 nM |
Click to Show More |
[16] |
2 |
VX-680 |
Drug Info
|
IC50 = 0.24 nM |
[17] |
3 |
PHA-739358 |
Drug Info
|
Ki = 2.5 nM |
[9] |
4 |
AT9283 |
Drug Info
|
IC50 = 3 nM |
[3] |
5 |
AMG 900 |
Drug Info
|
IC50 = 5 nM |
[18] |
6 |
CYC116 |
Drug Info
|
Ki = 8 nM |
[10] |
7 |
ABT-348 |
Drug Info
|
IC50 = 12 nM |
[5] |
8 |
GSK1070916 |
Drug Info
|
Ki = 490 nM |
[13] |
Co-Target Name |
Vascular endothelial growth factor receptor 3 (FLT-4) |
Clinical trial Target |
UniProt ID |
VGFR3_HUMAN
|
Gene Name |
FLT4
|
Synonyms |
VEGFR3; VEGFR-3; VEGF-3 receptor; Tyrosine-protein kinase receptor FLT4; Fms-like tyrosine kinase 4 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
Click to Show More |
[2] |
2 |
GSK1070916 |
Drug Info
|
IC50 = 74 nM |
[13] |
3 |
PHA-739358 |
Drug Info
|
IC50 = 161 nM |
[9] |
Co-Target Name |
Glycogen synthase kinase-3 beta (GSK-3B) |
Clinical trial Target |
UniProt ID |
GSK3B_HUMAN
|
Gene Name |
GSK3B
|
Synonyms |
Serine/threonine-protein kinase GSK3B; GSK-3 beta |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
Aurora kinase C (AURKC) |
Clinical trial Target |
UniProt ID |
AURKC_HUMAN
|
Gene Name |
AURKC
|
Synonyms |
Serine/threonine-protein kinase aurora-C; STK13; Aurora/Ipl1/Eg2 protein 2; Aurora/Ipl1-related kinase 3; Aurora-related kinase 3; Aurora-C; Aurora 3; ARK3; ARK-3; AIRK3; AIK3; AIE2 |
Representative Drug(s) |
AMG 900 |
Drug Info
|
IC50 = 1 nM |
Click to Show More |
[18] |
2 |
GSK1070916 |
Drug Info
|
Ki = 1.5 nM |
[13] |
3 |
VX-680 |
Drug Info
|
IC50 = 4.6 nM |
[19] |
4 |
MK-5108 |
Drug Info
|
IC50 = 12 nM |
[16] |
5 |
AZD-1152-HQPA |
Drug Info
|
Ki = 17 nM |
[15] |
6 |
PHA-739358 |
Drug Info
|
IC50 = 61 nM |
[9] |
7 |
CYC116 |
Drug Info
|
IC50 = 65 nM |
[3] |
8 |
Rosiglitazone + metformin |
Drug Info
|
IC50 = 210 nM |
[22] |
Co-Target Name |
TYK2 tyrosine kinase (TYK2) |
Clinical trial Target |
UniProt ID |
TYK2_HUMAN
|
Gene Name |
TYK2
|
Synonyms |
Non-receptor tyrosine-protein kinase TYK2 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
Yes tyrosine kinase (YES) |
Clinical trial Target |
UniProt ID |
YES_HUMAN
|
Gene Name |
YES1
|
Synonyms |
p61-Yes; Yes p59-Fyn; Yes Protooncogene Syn; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
Tyrosine-protein kinase Mer (MERTK) |
Clinical trial Target |
UniProt ID |
MERTK_HUMAN
|
Gene Name |
MERTK
|
Synonyms |
Receptor tyrosine kinase MerTK; Proto-oncogene c-Mer |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
Macrophage colony-stimulating factor 1 receptor (CSF1R) |
Clinical trial Target |
UniProt ID |
CSF1R_HUMAN
|
Gene Name |
CSF1R
|
Synonyms |
Proto-oncogene c-Fms; M-CSF-R; FMS; CSF-1R; CSF-1-R; CSF-1 receptor; CD115 |
Representative Drug(s) |
ABT-348 |
Drug Info
|
Ki = 3.162 nM |
[1] |
Co-Target Name |
Fibroblast growth factor receptor 3 (FGFR3) |
Clinical trial Target |
UniProt ID |
FGFR3_HUMAN
|
Gene Name |
FGFR3
|
Synonyms |
JTK4; FGFR-3; CD333 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
Co-Target Name |
Vascular endothelial growth factor receptor 1 (FLT-1) |
Clinical trial Target |
UniProt ID |
VGFR1_HUMAN
|
Gene Name |
FLT1
|
Synonyms |
Vascular permeability factor receptor; VEGFR1; VEGFR-1; VEGF-1 receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT; FLT |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
Click to Show More |
[2] |
2 |
Rosiglitazone + metformin |
Drug Info
|
IC50 = 28 nM |
[14] |
3 |
ABT-348 |
Drug Info
|
IC50 = 32 nM |
[5] |
4 |
GSK1070916 |
Drug Info
|
IC50 = 42 nM |
[13] |
Co-Target Name |
Protein delta homolog 1 (DLK1) |
Clinical trial Target |
UniProt ID |
DLK1_HUMAN
|
Gene Name |
DLK1
|
Synonyms |
pG2; DLK-1 |
Representative Drug(s) |
VX-680 |
Drug Info
|
Ki = 35.8 nM |
[20] |
Co-Target Name |
Angiopoietin 1 receptor (TEK) |
Clinical trial Target |
UniProt ID |
TIE2_HUMAN
|
Gene Name |
TEK
|
Synonyms |
hTIE2; VMCM1; VMCM; Tyrosine-protein kinase receptor TIE-2; Tyrosine-protein kinase receptor TEK; Tyrosine kinase with Ig and EGF homology domains-2; Tunica interna endothelial cell kinase; TIE2; P140 TEK; Endothelial tyrosine kinase; Endothelial Cell-Specific Receptor TIE-2; CD202b antigen; CD202b |
Representative Drug(s) |
GSK1070916 |
Drug Info
|
IC50 = 59 nM |
[13] |
Co-Target Name |
Receptor-interacting protein 1 (RIPK1) |
Clinical trial Target |
UniProt ID |
RIPK1_HUMAN
|
Gene Name |
RIPK1
|
Synonyms |
Receptor-interacting serine/threonine-protein kinase 1; RIP1; RIP-1; RIP; Cell death protein RIP |
Representative Drug(s) |
VX-680 |
Drug Info
|
IC50 = 208 nM |
[21] |
Co-Target Name |
Cyclin-dependent kinase 2 (CDK2) |
Clinical trial Target |
UniProt ID |
CDK2_HUMAN
|
Gene Name |
CDK2
|
Synonyms |
Sin3 associated polypeptide; SIN3-associated protein; P33 protein kinase; Cell division protein kinase 2; CDKN2 |
Representative Drug(s) |
CYC116 |
Drug Info
|
Ki = 390 nM |
Click to Show More |
[10] |
2 |
PHA-739358 |
Drug Info
|
IC50 = 462 nM |
[9] |
Co-Target Name |
Maternal embryonic leucine zipper kinase (MELK) |
Clinical trial Target |
UniProt ID |
MELK_HUMAN
|
Gene Name |
MELK
|
Synonyms |
Protein kinase PK38; Protein kinase Eg3 |
Representative Drug(s) |
VX-680 |
Drug Info
|
IC50 = 420 nM |
Click to Show More |
[22] |
2 |
AT9283 |
Drug Info
|
IC50 = 685 nM |
[23] |
Co-Target Name |
Cyclin-dependent kinase 9 (CDK9) |
Clinical trial Target |
UniProt ID |
CDK9_HUMAN
|
Gene Name |
CDK9
|
Synonyms |
Tat-associated kinase complex catalytic subunit; TAK; Similar to cyclin-dependent kinase 9; Serine/threonine-protein kinase PITALRE; Cyclin-dependent protein kinase Cdk9; Cell division protein kinase 9; Cell division cycle 2-like protein kinase 4; CDC2L4; CDC2-related kinase; C-2K |
Representative Drug(s) |
CYC116 |
Drug Info
|
Ki = 480 nM |
[10] |
Co-Target Name |
Positive transcription elongation factor b (P-TEFb) |
Clinical trial Target |
UniProt ID |
CDK9_HUMAN-CCNT1_HUMAN
|
Gene Name |
CDK9-CCNT1
|
Synonyms |
P-TEFb |
Representative Drug(s) |
CYC116 |
Drug Info
|
Ki = 480 nM |
[10] |
Co-Target Name |
Ribosomal protein S6 kinase beta-1 (S6K1) |
Clinical trial Target |
UniProt ID |
KS6B1_HUMAN
|
Gene Name |
RPS6KB1
|
Synonyms |
p70-S6K 1; p70 ribosomal S6 kinase alpha; p70 S6KA; p70 S6K-alpha; p70 S6 kinase alpha; Serine/threonine-protein kinase 14A; STK14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; P70-S6K; 70 kDa ribosomal protein S6 kinase 1 |
Representative Drug(s) |
CYC116 |
Drug Info
|
Ki = 540 nM |
[10] |
Co-Target Name |
Ribosomal protein S6 kinase alpha-3 (RSK3) |
Patented-recorded Target |
UniProt ID |
KS6A3_HUMAN
|
Gene Name |
RPS6KA3
|
Synonyms |
pp90RSK2; p90RSK3; p90-RSK 3; S6K-alpha-3; Ribosomal S6 kinase 2; RSK2; RSK-2; MAPKAPK1B; MAPKAPK-1b; MAPKAP kinase 1b; MAPK-activated protein kinase 1b; MAP kinase-activated protein kinase 1b; Insulin-stimulated protein kinase 1; ISPK1; ISPK-1; 90 kDa ribosomal protein S6 kinase 3 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
NF-kappa-B-activating kinase (TBK1) |
Patented-recorded Target |
UniProt ID |
TBK1_HUMAN
|
Gene Name |
TBK1
|
Synonyms |
TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK |
Representative Drug(s) |
VX-680 |
Drug Info
|
IC50 = 6.22 nM |
[24] |
Co-Target Name |
Pyruvate dehydrogenase kinase 1 (PDHK1) |
Patented-recorded Target |
UniProt ID |
PDK1_HUMAN
|
Gene Name |
PDK1
|
Synonyms |
Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; PDHK1; PDH kinase 1 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
Co-Target Name |
Discoidin domain-containing receptor 2 (DDR2) |
Patented-recorded Target |
UniProt ID |
DDR2_HUMAN
|
Gene Name |
DDR2
|
Synonyms |
Tyrosine-protein kinase TYRO10; Receptor protein-tyrosine kinase TKT; Neurotrophic tyrosine kinase, receptor-related 3; Discoidin domain-containing receptor tyrosine kinase 2; Discoidin domain receptor 2; DDR2; CD167 antigen-like family member B |
Representative Drug(s) |
VX-680 |
Drug Info
|
IC50 = 18 nM |
[25] |
Co-Target Name |
Ribosomal protein S6 kinase alpha-2 (RSK2) |
Literature-reported Target |
UniProt ID |
KS6A2_HUMAN
|
Gene Name |
RPS6KA2
|
Synonyms |
pp90RSK3; p90RSK2; p90-RSK 2; S6K-alpha-2; Ribosomal S6 kinase 3; RSK3; RSK-3; MAPKAPK1C; MAPKAPK-1c; MAPKAP kinase 1c; MAPK-activated protein kinase 1c; MAP kinase-activated protein kinase 1c; 90 kDa ribosomal protein S6 kinase 2 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 1 nM |
[2] |
Co-Target Name |
Protein kinase D (PRKD1) |
Literature-reported Target |
UniProt ID |
KPCD1_HUMAN
|
Gene Name |
PRKD1
|
Synonyms |
nPKC-mu; nPKC-D1; Serine/threonine-protein kinase D1; Protein kinase C mu type; PRKCM; PKD1; PKD |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
Co-Target Name |
Cytoplasmic DRAK1 (STK17A) |
Literature-reported Target |
UniProt ID |
ST17A_HUMAN
|
Gene Name |
STK17A
|
Synonyms |
Serine/threonine-protein kinase 17A; STK17A; DAP kinase-related apoptosis-inducing protein kinase 1 |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
Co-Target Name |
Polo-like kinase 4 (PLK4) |
Literature-reported Target |
UniProt ID |
PLK4_HUMAN
|
Gene Name |
PLK4
|
Synonyms |
Serine/threonine-protein kinase Sak; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase 18; STK18; SAK; PLK-4 |
Representative Drug(s) |
VX-680 |
Drug Info
|
Ki = 11 nM |
[26] |
Co-Target Name |
Salt-inducible kinase 1 (SIK1) |
Literature-reported Target |
UniProt ID |
SIK1_HUMAN
|
Gene Name |
SIK1
|
Synonyms |
Serine/threonine-protein kinase SNF1LK; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SIK1; SNF1LK; SIK-1; SIK |
Representative Drug(s) |
GSK1070916 |
Drug Info
|
IC50 = 70 nM |
[13] |
Co-Target Name |
STE20-related serine/threonine-protein kinase (SLK) |
Literature-reported Target |
UniProt ID |
SLK_HUMAN
|
Gene Name |
SLK
|
Synonyms |
hSLK; STE20-related kinase; STE20-like kinase |
Representative Drug(s) |
PHA-739358 |
Drug Info
|
IC50 = 621 nM |
[9] |
Co-Target Name |
Aurora kinase A-interacting protein (AURKAIP1) |
Co-Target |
UniProt ID |
AKIP_HUMAN
|
Gene Name |
AURKAIP1
|
Synonyms |
Mitochondrial small ribosomal subunit protein mS38; AURKA-interacting protein; 28S ribosomal protein S38, mitochondrial; MRP-S38 |
Representative Drug(s) |
VX-680 |
Drug Info
|
Ki = 0.6 nM |
[8] |
Co-Target Name |
Aurora kinase C-Inner centromere protein complex (AURKC-INCENP) |
Co-Target |
UniProt ID |
AURKC_HUMAN-INCE_HUMAN
|
Gene Name |
AURKC-INCENP
|
Representative Drug(s) |
GSK1070916 |
Drug Info
|
Ki = 1.5 nM |
[18] |
Co-Target Name |
Ribosomal protein S6 kinase alpha 4 (RPS6KA4) |
Co-Target |
UniProt ID |
KS6A4_HUMAN
|
Gene Name |
RPS6KA4
|
Synonyms |
Ribosomal protein S6 kinase alpha-4; S6K-alpha-4; 90 kDa ribosomal protein S6 kinase 4; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinase B; RSKB |
Representative Drug(s) |
AT9283 |
Drug Info
|
IC50 = 10 nM |
[2] |
Co-Target Name |
Aurora kinase A-Targeting protein for Xklp2 complex (AURKA-TPX2) |
Co-Target |
UniProt ID |
AURKA_HUMAN-TPX2_HUMAN
|
Gene Name |
AURKA-TPX2
|
Representative Drug(s) |
TAK-901 |
Drug Info
|
IC50 = 21 nM |
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[18] |
2 |
GSK1070916 |
Drug Info
|
Ki = 490 nM |
[18] |
Co-Target Name |
Cyclin dependent kinase 2-G1/S specific cyclin E1 complex (CDK2-CCNE1) |
Co-Target |
UniProt ID |
CDK2_HUMAN-CCNE1_HUMAN
|
Gene Name |
CDK2-CCNE1
|
Representative Drug(s) |
CYC116 |
Drug Info
|
Ki = 390 nM |
[10] |