Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T55610 Target Info
Target Name Hypoxia-inducible factor 1 alpha (HIF-1A)
Synonyms
bHLHe78; Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; Member of PAS protein 1; MOP1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1 A; Hypoxia inducible factor 1; HIF1-alpha; HIF1 alpha; HIF-1alpha; HIF-1-alpha; HIF-1 alpha; Class E basic helix-loop-helix protein 78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name HIF1A
UniProt ID
HIF1A_HUMAN
Co-Targets of This Target  Top
Co-Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target
UniProt ID FGFR1_HUMAN
Gene Name FGFR1
Synonyms
c-fgr; bFGF-R-1; bFGF-R; N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT2; FLT-2; FLG; FGFR-1; FGFBR; CEK; CD331 antigen; CD331; Basic fibroblast growth factor receptor 1; BFGFR
    Click to Show/Hide
Representative Drug(s) HIF-1alpha Drug Info IC50 = 48 nM [1]
Co-Target Name Fibroblast growth factor receptor (FGFR) Clinical trial Target
UniProt ID FGFR1_HUMAN; FGFR2_HUMAN; FGFR3_HUMAN; FGFR4_HUMAN
Gene Name NO-GeName
Synonyms
FGF receptor
    Click to Show/Hide
Representative Drug(s) HIF-1alpha Drug Info IC50 = 60 nM [2]
References  Top
REF 1 Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity. J Med Chem. 2001 Jun 7;44(12):1915-26.
REF 2 Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem. 1997 Jul 18;40(15):2296-303.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.