Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55959 | Target Info | |||
| Target Name | Dopamine transporter (DAT) | ||||
| Synonyms |
Solute carrier family 6 member 3; Sodium-dependent dopamine transporter; DAT1; DAT; DA transporter
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| Target Type | Successful Target | ||||
| Gene Name | SLC6A3 | ||||
| Biochemical Class | Neurotransmitter:sodium symporter | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Serotonin transporter (SERT) | Successful Target | ||||
| UniProt ID | SC6A4_HUMAN | |||||
| Gene Name | SLC6A4 | |||||
| Synonyms |
Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter
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| Representative Drug(s) | METHYLENEDIOXYMETHAMPHETAMINE | Drug Info | Ki = 0.73 nM | Click to Show More | [1] | |
| 2 | Amitifadine | Drug Info | IC50 = 12.3 nM | [3] | ||
| 3 | Cocaine | Drug Info | Ki = 45 nM | [4] | ||
| Co-Target Name | Voltage-gated potassium channel Kv11.1 (KCNH2) | Successful Target | ||||
| UniProt ID | KCNH2_HUMAN | |||||
| Gene Name | KCNH2 | |||||
| Synonyms |
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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| Representative Drug(s) | Cocaine | Drug Info | IC50 = 4.4 nM | [2] | ||
| Co-Target Name | Norepinephrine transporter (NET) | Successful Target | ||||
| UniProt ID | SC6A2_HUMAN | |||||
| Gene Name | SLC6A2 | |||||
| Synonyms |
Solute carrier family 6 member 2; Sodium-dependent noradrenaline transporter; SLC6A2; NET1; NET; NAT1
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| Representative Drug(s) | Amitifadine | Drug Info | IC50 = 22.8 nM | Click to Show More | [3] | |
| 2 | Methylphenidate | Drug Info | IC50 = 61 nM | [5] | ||
| 3 | Cocaine | Drug Info | Ki = 108 nM | [6] | ||
| 4 | METHYLENEDIOXYMETHAMPHETAMINE | Drug Info | Ki = 398 nM | [7] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Carbon-11 labeled indolylpropylamine analog as a new potential PET agent for imaging of the serotonin transporter. Bioorg Med Chem. 2008 Jun 15;16(12):6364-70. | ||||
| REF 2 | Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. J Med Chem. 2002 Aug 29;45(18):3844-53. | ||||
| REF 3 | Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. | ||||
| REF 4 | Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes. J Med Chem. 2005 Nov 17;48(23):7437-44. | ||||
| REF 5 | Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. | ||||
| REF 6 | Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorg Med Chem Lett. 2003 Feb 10;13(3):513-7. | ||||
| REF 7 | An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3411-5. | ||||
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