Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61622 | Target Info | |||
| Target Name | Angiotensinogenase renin (REN) | ||||
| Synonyms |
Renin; Angiotensinogenase
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| Target Type | Successful Target | ||||
| Gene Name | REN | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Human immunodeficiency virus Protease (HIV PR) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV PR | |||||
| Synonyms |
HIV Retropepsin; HIV PR
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| Representative Drug(s) | Aliskiren | Drug Info | Ki = 76.5 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations. J Med Chem. 2012 Jun 28;55(12):5784-96. | ||||
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