Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62151 | Target Info | |||
| Target Name | Monoamine oxidase (MAO) | ||||
| Synonyms |
Human monoamine oxidase
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Membrane copper amine oxidase (AOC3) | Successful Target | ||||
| UniProt ID | AOC3_HUMAN | |||||
| Gene Name | AOC3 | |||||
| Synonyms |
Vascular adhesion protein-1; Vascular adhesion protein 1; VAP1; VAP-1; Semicarbazide-sensitive amine oxidase; SSAO; Membrane primary amine oxidase; HPAO; Copper amine oxidase
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| Representative Drug(s) | Phenelzine | Drug Info | IC50 = 19.95 nM | [1] | ||
| Co-Target Name | Opioid receptor sigma 1 (OPRS1) | Successful Target | ||||
| UniProt ID | SGMR1_HUMAN | |||||
| Gene Name | SIGMAR1 | |||||
| Synonyms |
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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| Representative Drug(s) | Moclobemide | Drug Info | Ki ~ 100 nM | [2] | ||
| Co-Target Name | Amyloid beta A4 protein (APP) | Successful Target | ||||
| UniProt ID | A4_HUMAN | |||||
| Gene Name | APP | |||||
| Synonyms |
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
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| Representative Drug(s) | Methylene blue | Drug Info | IC50 = 500 nM | [3] | ||
| Co-Target Name | Microtubule-associated protein tau (MAPT) | Clinical trial Target | ||||
| UniProt ID | TAU_HUMAN | |||||
| Gene Name | MAPT | |||||
| Synonyms |
tau; Paired helical filamenttau; Paired helical filament-tau; Neurofibrillary tangle protein; MTBT1; MAPTL
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| Representative Drug(s) | Methylene blue | Drug Info | EC50 = 130 nM | [4] | ||
| Co-Target Name | Sigma intracellular receptor 2 (TMEM97) | Clinical trial Target | ||||
| UniProt ID | SGMR2_HUMAN | |||||
| Gene Name | TMEM97 | |||||
| Synonyms |
Transmembrane protein 97; Sigma2 receptor; Sigma-2 receptor; Meningioma-associated protein 30; MAC30
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| Representative Drug(s) | Moclobemide | Drug Info | Ki ~ 200 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis, in vitro activity, and three-dimensional quantitative structure-activity relationship of novel hydrazine inhibitors of human vascular adhesion protein-1. J Med Chem. 2010 Sep 9;53(17):6301-15. | ||||
| REF 2 | Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands. Eur J Med Chem. 2017 Sep 29;138:964-78. | ||||
| REF 3 | Design and synthesis of curcumin derivatives as tau and amyloid beta dual aggregation inhibitors. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5024-8. | ||||
| REF 4 | Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. Eur J Med Chem. 2019 May 1;169:200-223. | ||||
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