Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T63816 Target Info
Target Name Histone deacetylase 4 (HDAC4)
Synonyms
KIAA0288; HD4
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Target Type Clinical trial Target
Gene Name HDAC4
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
HDAC4_HUMAN
Co-Targets of This Target  Top
Co-Target Name Histone deacetylase 1 (HDAC1) Successful Target
UniProt ID HDAC1_HUMAN
Gene Name HDAC1
Synonyms
RPD3L1; HD1
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 0.03 nM [1]
Co-Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target
UniProt ID HDAC2_HUMAN
Gene Name HDAC2
Synonyms
HD2
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 0.06 nM [1]
Co-Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target
UniProt ID HDAC3_HUMAN
Gene Name HDAC3
Synonyms
SMAP45; RPD32; RPD3-2; HD3
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 2.1 nM [1]
Co-Target Name Histone deacetylase 6 (HDAC6) Clinical trial Target
UniProt ID HDAC6_HUMAN
Gene Name HDAC6
Synonyms
KIAA0901; JM21; HD6
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 16.9 nM [1]
Co-Target Name Histone deacetylase 10 (HDAC10) Patented-recorded Target
UniProt ID HDA10_HUMAN
Gene Name HDAC10
Synonyms
Polyamine deacetylase HDAC10; HD10
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 0.05 nM [1]
Co-Target Name Histone deacetylase 11 (HDAC11) Patented-recorded Target
UniProt ID HDA11_HUMAN
Gene Name HDAC11
Synonyms
HD11
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 0.07 nM [1]
Co-Target Name Histone deacetylase 8 (HDAC8) Patented-recorded Target
UniProt ID HDAC8_HUMAN
Gene Name HDAC8
Synonyms
Histone deacetylase-8; HDACL1; HD8; CDA07
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 0.5 nM [1]
Co-Target Name Histone deacetylase 7 (HDAC7) Patented-recorded Target
UniProt ID HDAC7_HUMAN
Gene Name HDAC7
Synonyms
Histone deacetylase 7A; HDAC7A; HD7a; HD7
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 1.7 nM [2]
Co-Target Name Histone deacetylase 5 (HDAC5) Patented-recorded Target
UniProt ID HDAC5_HUMAN
Gene Name HDAC5
Synonyms
KIAA0600; HD5; Antigen NY-CO-9
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 2.1 nM [1]
Co-Target Name Histone deacetylase 9 (HDAC9) Patented-recorded Target
UniProt ID HDAC9_HUMAN
Gene Name HDAC9
Synonyms
MITR; MEF2-interacting transcription repressor MITR; KIAA0744; Histone deacetylase-related protein; Histone deacetylase 7B; HDRP; HDAC7B; HDAC7; HD9; HD7b
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Representative Drug(s) JNJ-26481585 Drug Info Ki = 3.8 nM [1]
Co-Target Name Histone deacetylase 3-Nuclear receptor corepressor 2 complex (HDAC3-NCOR2) Co-Target
UniProt ID HDAC3_HUMAN-NCOR2_HUMAN
Gene Name HDAC3-NCOR2
Representative Drug(s) JNJ-26481585 Drug Info IC50 = 4.86 nM [3]
References  Top
REF 1 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). Bioorg Med Chem. 2015 Aug 15;23(16):5151-5.
REF 2 Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2985-92.
REF 3 Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. J Med Chem. 2016 Oct 13;59(19):8967-9004.

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