Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T70518 Target Info
Target Name S-nitrosoglutathione reductase (CBR1)
Synonyms
ProstaglandinE(2) 9reductase; Prostaglandin 9ketoreductase; NADPHdependent carbonyl reductase 1; Carbonyl reductase [NADPH] 1; CBR1; 15hydroxyprostaglandin dehydrogenase [NADP(+)]
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Target Type Clinical trial Target
Gene Name CBR1
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
CBR1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Alcohol dehydrogenase class III (ADH5) Co-Target
UniProt ID ADHX_HUMAN
Gene Name ADH5
Synonyms
Alcohol dehydrogenase class-3; Alcohol dehydrogenase 5; Alcohol dehydrogenase class chi chain; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase
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Representative Drug(s) N6022 Drug Info IC50 = 20 nM [1]
Co-Target Name Cytochrome P450 2C19 (CYP2C19) Co-Target
UniProt ID CP2CJ_HUMAN
Gene Name CYP2C19
Synonyms
Fenbendazole monooxygenase (4'-hydroxylating); (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
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Representative Drug(s) N6022 Drug Info IC50 = 770 nM [2]
References  Top
REF 1 Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3766-3773.
REF 2 Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases. ACS Med Chem Lett. 2011 Mar 11;2(5):402-6.

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