Co-Target(s) Information
Target General Information | Top | ||||
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Target ID | T71167 | Target Info | |||
Target Name | Oxysterols receptor LXR (NR1H) | ||||
Target Type | Clinical trial Target | ||||
Gene Name | NO-GeName | ||||
Biochemical Class | Nuclear hormone receptor | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
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Co-Target Name | Glucocorticoid receptor (NR3C1) | Successful Target | ||||
UniProt ID | GCR_HUMAN | |||||
Gene Name | NR3C1 | |||||
Synonyms |
Nuclear receptor subfamily 3 group C member 1; GRL; GR
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Representative Drug(s) | LXR 623 | Drug Info | IC50 = 1000 nM | [1] | ||
Co-Target Name | Progesterone receptor (PGR) | Successful Target | ||||
UniProt ID | PRGR_HUMAN | |||||
Gene Name | PGR | |||||
Synonyms |
PR; Nuclear receptor subfamily 3 group C member 3; NR3C3
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Representative Drug(s) | LXR 623 | Drug Info | IC50 ~ 1000 nM | [1] | ||
Co-Target Name | Pregnane X receptor (NR1I2) | Literature-reported Target | ||||
UniProt ID | NR1I2_HUMAN | |||||
Gene Name | NR1I2 | |||||
Synonyms |
Steroid and xenobiotic receptor; SXR; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
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Representative Drug(s) | BMS-852927 | Drug Info | EC50 = 1000 nM | [2] |
References | Top | ||||
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REF 1 | Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. | ||||
REF 2 | Discovery of Highly Potent Liver X Receptor beta Agonists. ACS Med Chem Lett. 2016 Oct 23;7(12):1207-12. |
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