Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T71167 | Target Info | |||
| Target Name | Oxysterols receptor LXR (NR1H) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Glucocorticoid receptor (NR3C1) | Successful Target | ||||
| UniProt ID | GCR_HUMAN | |||||
| Gene Name | NR3C1 | |||||
| Synonyms |
Nuclear receptor subfamily 3 group C member 1; GRL; GR
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| Representative Drug(s) | LXR 623 | Drug Info | IC50 = 1000 nM | [1] | ||
| Co-Target Name | Progesterone receptor (PGR) | Successful Target | ||||
| UniProt ID | PRGR_HUMAN | |||||
| Gene Name | PGR | |||||
| Synonyms |
PR; Nuclear receptor subfamily 3 group C member 3; NR3C3
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| Representative Drug(s) | LXR 623 | Drug Info | IC50 ~ 1000 nM | [1] | ||
| Co-Target Name | Pregnane X receptor (NR1I2) | Literature-reported Target | ||||
| UniProt ID | NR1I2_HUMAN | |||||
| Gene Name | NR1I2 | |||||
| Synonyms |
Steroid and xenobiotic receptor; SXR; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
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| Representative Drug(s) | BMS-852927 | Drug Info | EC50 = 1000 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. | ||||
| REF 2 | Discovery of Highly Potent Liver X Receptor beta Agonists. ACS Med Chem Lett. 2016 Oct 23;7(12):1207-12. | ||||
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