Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72252 | Target Info | |||
| Target Name | Caspase-7 (CASP7) | ||||
| Synonyms |
MCH3; ICE-like apoptotic protease 3; ICE-LAP3; CMH-1; CASP-7; Apoptotic protease Mch-3
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| Target Type | Clinical trial Target | ||||
| Gene Name | CASP7 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Caspase-3 (CASP3) | Clinical trial Target | ||||
| UniProt ID | CASP3_HUMAN | |||||
| Gene Name | CASP3 | |||||
| Synonyms |
Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; Caspase 3; CPP32; CPP-32; CASP-3; Apopain
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| Representative Drug(s) | isatin sulfonamide 34 | Drug Info | Ki = 1.2 nM | [1] | ||
| Co-Target Name | Caspase-9 (CASP9) | Clinical trial Target | ||||
| UniProt ID | CASP9_HUMAN | |||||
| Gene Name | CASP9 | |||||
| Synonyms |
MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease activating factor 3; Apoptotic protease Mch-6; APAF-3
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| Representative Drug(s) | isatin sulfonamide 34 | Drug Info | Ki = 120 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. | ||||
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