Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T74977 Target Info
Target Name Dual specificity protein kinase TTK (MPS1)
Synonyms
Tyrosine threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; MPS1L1
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Target Type Clinical trial Target
Gene Name TTK
Biochemical Class Kinase
UniProt ID
TTK_HUMAN
Co-Targets of This Target  Top
Co-Target Name Leucine-rich repeat kinase 2 (LRRK2) Clinical trial Target
UniProt ID LRRK2_HUMAN
Gene Name LRRK2
Synonyms
PARK8; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
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Representative Drug(s) BOS172722 Drug Info IC50 = 48 nM [1]
Co-Target Name Stress-activated protein kinase JNK1 (JNK1) Clinical trial Target
UniProt ID MK08_HUMAN
Gene Name MAPK8
Synonyms
Stress-activated protein kinase 1c; SAPK1c; PRKM8; Mitogen-activated protein kinase 8; MAPK 8; MAP kinase 8; JNK-46; C-Jun N-terminal kinase 1
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Representative Drug(s) BOS172722 Drug Info IC50 = 92 nM [1]
Co-Target Name Stress-activated protein kinase JNK2 (JNK2) Patented-recorded Target
UniProt ID MK09_HUMAN
Gene Name MAPK9
Synonyms
Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
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Representative Drug(s) BOS172722 Drug Info IC50 = 76 nM [1]
Co-Target Name Stress-activated protein kinase JNK3 (JNK3) Patented-recorded Target
UniProt ID MK10_HUMAN
Gene Name MAPK10
Synonyms
Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
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Representative Drug(s) BOS172722 Drug Info IC50 = 242 nM [1]
Co-Target Name Cyclin dependent kinase 2-Cyclin A2 complex (CDK2-CCNA2) Co-Target
UniProt ID CDK2_HUMAN-CCNA2_HUMAN
Gene Name CDK2-CCNA2
Representative Drug(s) BOS172722 Drug Info Ki = 510 nM [1]
References  Top
REF 1 Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N. J Med Chem. 2018 Sep 27;61(18):8226-40.

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