Co-Target(s) Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T78111 | Target Info | |||
Target Name | Nicotinic acetylcholine receptor (nAChR) | ||||
Synonyms |
nAChR; Nicotinergic acetylcholine receptor
Click to Show/Hide
|
||||
Target Type | Successful Target | ||||
Gene Name | NO-GeName | ||||
Biochemical Class | Ion transport | ||||
UniProt ID |
Co-Targets of This Target | Top | |||||
---|---|---|---|---|---|---|
Co-Target Name | Neuronal acetylcholine receptor alpha-7 (CHRNA7) | Successful Target | ||||
UniProt ID | ACHA7_HUMAN | |||||
Gene Name | CHRNA7 | |||||
Synonyms |
Nicotinic acetylcholine receptor subunit alpha 7; Nicotinic acetylcholine receptor alpha7; CHRNA7; Alpha7 nicotinic receptor; Alpha7 nAChR; Alpha-7 nAChR; Alpha(7) nicotinic receptor
Click to Show/Hide
|
|||||
Representative Drug(s) | A-85380 | Drug Info | Ki = 148 nM | Click to Show More | [1] | |
2 | Nicotine | Drug Info | Ki = 620 nM | [2] | ||
Co-Target Name | Neuronal acetylcholine receptor alpha-3 (CHRNA3) | Co-Target | ||||
UniProt ID | ACHA3_HUMAN | |||||
Gene Name | CHRNA3 | |||||
Synonyms |
Neuronal acetylcholine receptor subunit alpha-3
Click to Show/Hide
|
|||||
Representative Drug(s) | Nicotine | Drug Info | IC50 = 45 nM | Click to Show More | [3] | |
2 | A-85380 | Drug Info | EC50 = 700 nM | [1] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors. J Med Chem. 1998 Feb 12;41(4):407-12. | ||||
REF 2 | Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions. J Med Chem. 1999 Aug 12;42(16):3066-74. | ||||
REF 3 | Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J Agric Food Chem. 2000 Dec;48(12):6016-24. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.