Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T81358 Target Info
Target Name CDC7-related kinase (CDC7)
Synonyms
huCdc7; HsCdc7; Cell division cycle 7related protein kinase; Cell division cycle 7-related protein kinase; CDC7related kinase; CDC7L1
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Target Type Clinical trial Target
Gene Name CDC7
Biochemical Class Kinase
UniProt ID
CDC7_HUMAN
Co-Targets of This Target  Top
Co-Target Name Rho-associated protein kinase 1 (ROCK1) Successful Target
UniProt ID ROCK1_HUMAN
Gene Name ROCK1
Synonyms
Rok; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated kinase 1; Rho kinase; ROCK1; ROCK; P160ROCK; P160(rock); P160 ROCK-1; Let-502 kinase
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Representative Drug(s) TAK-931 Drug Info IC50 = 430 nM [1]
Co-Target Name Serine/threonine-protein kinase pim-1 (PIM1) Clinical trial Target
UniProt ID PIM1_HUMAN
Gene Name PIM1
Synonyms
Pim-1 proto-oncogene, serine/threonine kinase; PIM
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Representative Drug(s) BMS-863233 Drug Info IC50 = 42 nM [2]
Co-Target Name Casein kinase II alpha/beta complex (CSNK2A1-CSNK2B) Co-Target
UniProt ID CSK21_HUMAN-CSK2B_HUMAN
Gene Name CSNK2A1-CSNK2B
Synonyms
CK II alpha/beta
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Representative Drug(s) BMS-863233 Drug Info IC50 = 215 nM [2]
References  Top
REF 1 Discovery of a Novel, Highly Potent, and Selective Thieno[3,2- d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent. J Med Chem. 2020 Feb 13;63(3):1084-1104.
REF 2 Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.

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