Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81774 | Target Info | |||
| Target Name | Tubulin polymerization (TubP) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Proto-oncogene c-Src (SRC) | Successful Target | ||||
| UniProt ID | SRC_HUMAN | |||||
| Gene Name | SRC | |||||
| Synonyms |
pp60c-src; Tyrosine kinase (pp60(src)); Src tyrosine kinase; SRC1; Proto-oncogene tyrosine-protein kinase Src; Pp60(src); P60-Src; C-src TK; C-Src
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| Representative Drug(s) | Tirbanibulin | Drug Info | IC50 = 6.5 nM | [1] | ||
| Co-Target Name | Fusion protein Bcr-Abl (Bcr-Abl) | Successful Target | ||||
| UniProt ID | BCR_HUMAN-ABL1_HUMAN | |||||
| Gene Name | BCR-ABL1 | |||||
| Synonyms |
BCR-ABL fusion protein; BCR-ABL
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| Representative Drug(s) | Tirbanibulin | Drug Info | IC50 = 100 nM | [1] | ||
| Co-Target Name | Tyrosine-protein kinase Lyn (JTK8) | Clinical trial Target | ||||
| UniProt ID | LYN_HUMAN | |||||
| Gene Name | LYN | |||||
| Synonyms |
p56Lyn; p53Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Lck/Yes-related novel protein tyrosine kinase
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| Representative Drug(s) | Tirbanibulin | Drug Info | IC50 = 100 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361). J Med Chem. 2018 Jun 14;61(11):4704-4719. | ||||
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