Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T84621 Target Info
Target Name Steroid 11-beta-hydroxylase (CYP11B1)
Synonyms
S11BH; P450C11; P-450c11; CYPXIB1; CYP11B1
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Target Type Successful Target
Gene Name CYP11B1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
C11B1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Aromatase (CYP19A1) Successful Target
UniProt ID CP19A_HUMAN
Gene Name CYP19A1
Synonyms
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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Representative Drug(s) FADROZOLE Drug Info IC50 = 0.004 nM [1]
Co-Target Name Aldosterone synthase (CYP11B2) Clinical trial Target
UniProt ID C11B2_HUMAN
Gene Name CYP11B2
Synonyms
Steroid 18hydroxylase; Cytochrome P450C18; Cytochrome P450Aldo; Cytochrome P450 11B2, mitochondrial; CYPXIB2; CYP11B2; Aldosteronesynthesizing enzyme; ALDOS
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Representative Drug(s) FADROZOLE Drug Info IC50 = 0.8 nM Click to Show More [2]
2 Metyrapone Drug Info IC50 = 5 nM [3]
References  Top
REF 1 Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective. J Med Chem. 2016 Jun 9;59(11):5131-48.
REF 2 Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases. J Med Chem. 2013 Aug 8;56(15):6101-7.
REF 3 Potent 11beta-hydroxylase inhibitors with inverse metabolic stability in human plasma and hepatic S9 fractions to promote wound healing. J Med Chem. 2014 Sep 25;57(18):7811-7.

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