Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T84634 Target Info
Target Name Cytochrome P450 26 (CYP26A1)
Synonyms
Retinoic acid-metabolizing cytochrome; Retinoic acid inducible enzyme; Retinoic acid 4-hydroxylase; P450RAI; P450 retinoic acid-inactivating 1; HP450RAI; Cytochrome P450RAI; CYP26A1
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Target Type Clinical trial Target
Gene Name CYP26A1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
CP26A_HUMAN
Co-Targets of This Target  Top
Co-Target Name Aromatase (CYP19A1) Successful Target
UniProt ID CP19A_HUMAN
Gene Name CYP19A1
Synonyms
P-450AROM; Estrogen synthetase; Estrogen synthase; Cytochrome P450 19A1; Cytochrome P-450AROM; CYPXIX; CYP19; CYAR; ARO1
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Representative Drug(s) LIAROZOLE Drug Info IC50 = 5 nM [1]
Co-Target Name Cytochrome P450 24 (CYP24A1) Clinical trial Target
UniProt ID CP24A_HUMAN
Gene Name CYP24A1
Synonyms
Vitamin D(3) 24hydroxylase; Cytochrome P450CC24; CYP24A1; 24OHase; 1,25dihydroxyvitamin D(3) 24hydroxylase, mitochondrial
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Representative Drug(s) LIAROZOLE Drug Info IC50 = 2.3 nM [2]
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) LIAROZOLE Drug Info IC50 = 690 nM [3]
Co-Target Name Cytochrome P450 26B1 (CYP26B1) Co-Target
UniProt ID CP26B_HUMAN
Gene Name CYP26B1
Synonyms
Cytochrome P450 26A2; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450RAI-2; Retinoic acid-metabolizing cytochrome
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Representative Drug(s) Rambazole Drug Info IC50 = 0.46 nM Click to Show More [4]
2 LIAROZOLE Drug Info IC50 = 18 nM [4]
References  Top
REF 1 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
REF 2 Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem. 2014 Sep 25;57(18):7702-15.
REF 3 Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors. Bioorg Med Chem. 2015 Oct 15;23(20):6763-73.
REF 4 Development and Characterization of Novel and Selective Inhibitors of Cytochrome P450 CYP26A1, the Human Liver Retinoic Acid Hydroxylase. J Med Chem. 2016 Mar 24;59(6):2579-95.

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