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| Target General Information |
Top |
| Target ID |
T86052 |
Target Info
|
| Target Name |
Telomerase reverse transcriptase (TERT) |
| Synonyms |
Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2 |
| Target Type |
Clinical trial Target |
| Gene Name |
TERT |
| Biochemical Class |
Kinase |
| UniProt ID |
|
| Co-Targets of This Target |
Top |
| Co-Target Name |
Acetylcholinesterase (AChE) |
Successful Target |
| UniProt ID |
ACES_HUMAN
|
| Gene Name |
ACHE
|
| Synonyms |
YT; N-ACHE; ARACHE |
| Representative Drug(s) |
Berberine |
Drug Info
|
IC50 = 40 nM |
Click to Show More |
[1] |
| 2 |
Berberine |
Drug Info
|
IC50 = 100 nM |
[2] |
| Co-Target Name |
Cytochrome P450 1B1 (CYP1B1) |
Clinical trial Target |
| UniProt ID |
CP1B1_HUMAN
|
| Gene Name |
CYP1B1
|
| Synonyms |
CYPIB1 |
| Representative Drug(s) |
Berberine |
Drug Info
|
Ki = 44 nM |
[3] |
| References |
Top |
| REF 1 |
Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7.
|
| REF 2 |
Isolation of cholinesterase and beta-secretase 1 inhibiting compounds from Lycopodiella cernua. Bioorg Med Chem. 2015 Jul 1;23(13):3126-34.
|
| REF 3 |
Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
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