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Target General Information |
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Target ID |
T86052 |
Target Info
|
Target Name |
Telomerase reverse transcriptase (TERT) |
Synonyms |
Telomerase-associated protein 2; Telomerase catalytic subunit; TRT; TP2; TCS1; HEST2; EST2 |
Target Type |
Clinical trial Target |
Gene Name |
TERT |
Biochemical Class |
Kinase |
UniProt ID |
|
Co-Targets of This Target |
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Co-Target Name |
Acetylcholinesterase (AChE) |
Successful Target |
UniProt ID |
ACES_HUMAN
|
Gene Name |
ACHE
|
Synonyms |
YT; N-ACHE; ARACHE |
Representative Drug(s) |
Berberine |
Drug Info
|
IC50 = 40 nM |
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[1] |
2 |
Berberine |
Drug Info
|
IC50 = 100 nM |
[2] |
Co-Target Name |
Cytochrome P450 1B1 (CYP1B1) |
Clinical trial Target |
UniProt ID |
CP1B1_HUMAN
|
Gene Name |
CYP1B1
|
Synonyms |
CYPIB1 |
Representative Drug(s) |
Berberine |
Drug Info
|
Ki = 44 nM |
[3] |
References |
Top |
REF 1 |
Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7.
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REF 2 |
Isolation of cholinesterase and beta-secretase 1 inhibiting compounds from Lycopodiella cernua. Bioorg Med Chem. 2015 Jul 1;23(13):3126-34.
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REF 3 |
Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
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