Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86528 | Target Info | |||
| Target Name | Geranyltranstransferase (FDPS) | ||||
| Synonyms |
KIAA1293; Geranylgeranyl pyrophosphate synthase; Geranylgeranyl diphosphate synthase; GGPS1; GGPPSase; GGPP synthase; Farnesyltranstransferase; Farnesyl pyrophosphate synthase; Farnesyl diphosphate synthase; FPS protein; FPP synthase; Dimethylallyltranstransferase; (2E,6E)-farnesyl diphosphate synthase
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| Target Type | Successful Target | ||||
| Gene Name | FDPS | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
| UniProt ID | CAH2_HUMAN | |||||
| Gene Name | CA2 | |||||
| Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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| Representative Drug(s) | Zoledronate | Drug Info | IC50 = 62 nM | [1] | ||
| Co-Target Name | Carbonic anhydrase XIV (CA-XIV) | Successful Target | ||||
| UniProt ID | CAH14_HUMAN | |||||
| Gene Name | CA14 | |||||
| Synonyms |
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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| Representative Drug(s) | Zoledronate | Drug Info | IC50 = 92 nM | [2] | ||
| Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
| UniProt ID | CAH12_HUMAN | |||||
| Gene Name | CA12 | |||||
| Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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| Representative Drug(s) | Zoledronate | Drug Info | IC50 = 316 nM | [1] | ||
| Co-Target Name | Butyrophilin subfamily 3 member A1 (BTN3A1) | Co-Target | ||||
| UniProt ID | BT3A1_HUMAN | |||||
| Gene Name | BTN3A1 | |||||
| Synonyms |
DE AltName: CD_antigen=CD277
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| Representative Drug(s) | Zoledronate | Drug Info | EC50 = 486.6 nM | [3] | ||
| Co-Target Name | Geranylgeranyl pyrophosphate synthetase (GGPS1) | Co-Target | ||||
| UniProt ID | GGPPS_HUMAN | |||||
| Gene Name | GGPS1 | |||||
| Synonyms |
Geranylgeranyl pyrophosphate synthase; GGPP synthase; GGPPSase; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase
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| Representative Drug(s) | Minodronate | Drug Info | IC50 = 670 nM | [4] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2617-20. | ||||
| REF 2 | Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1941-3. | ||||
| REF 3 | Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vgamma9/Vdelta2 T-Cell Immune Responses. J Med Chem. 2018 Mar 8;61(5):2111-2117. | ||||
| REF 4 | Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64. | ||||
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