Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87023 | Target Info | |||
| Target Name | Platelet-activating factor receptor (PTAFR) | ||||
| Synonyms |
PTAFR; PAF-R
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| Target Type | Successful Target | ||||
| Gene Name | PTAFR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Histamine H1 receptor (H1R) | Successful Target | ||||
| UniProt ID | HRH1_HUMAN | |||||
| Gene Name | HRH1 | |||||
| Synonyms |
HH1R; H1R
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| Representative Drug(s) | RUPATADINE | Drug Info | IC50 = 3.9 nM | Click to Show More | [1] | |
| 2 | PegCNTF | Drug Info | IC50 = 100 nM | [1] | ||
| Co-Target Name | Cytochrome P450 2B6 (CYP2B6) | Literature-reported Target | ||||
| UniProt ID | CP2B6_HUMAN | |||||
| Gene Name | CYP2B6 | |||||
| Synonyms |
Cytochrome P450 IIB1; CYPIIB6; 1,4-cineole 2-exo-monooxygenase
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| Representative Drug(s) | Ticlopidine | Drug Info | Ki = 200 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. | ||||
| REF 2 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54. | ||||
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