Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T88240 Target Info
Target Name Bacterial Dihydropteroate synthetase (Bact folP)
Synonyms
folP; H2Pte synthase; Dihydropteroate synthase; Dihydropteroate pyrophosphorylase; DHPS
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Target Type Successful Target
Gene Name Bact folP
Biochemical Class Alkyl aryl transferase
UniProt ID
DHPS_ECOLI
Co-Targets of This Target  Top
Co-Target Name Carbonic anhydrase II (CA-II) Successful Target
UniProt ID CAH2_HUMAN
Gene Name CA2
Synonyms
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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Representative Drug(s) Sulfanilamide Drug Info Ki = 1.02 Ratio Click to Show More [1]
2 Sulfanilamide Drug Info Ki = 240 nM [3]
Co-Target Name Carbonic anhydrase XII (CA-XII) Successful Target
UniProt ID CAH12_HUMAN
Gene Name CA12
Synonyms
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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Representative Drug(s) Sulfanilamide Drug Info Ki = 37 nM [2]
Co-Target Name Carbonic anhydrase I (CA-I) Successful Target
UniProt ID CAH1_HUMAN
Gene Name CA1
Synonyms
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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Representative Drug(s) Sulfanilamide Drug Info Ki = 300 nM [4]
Co-Target Name Solute carrier family 47 member 1 (SLC47A1) Successful Target
UniProt ID S47A1_HUMAN
Gene Name SLC47A1
Synonyms
hMATE-1; Multidrug and toxin extrusion protein 1; MATE1; MATE-1
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Representative Drug(s) Chlorhexidine Drug Info IC50 = 700 nM [5]
Co-Target Name Endothelin A receptor (EDNRA) Successful Target
UniProt ID EDNRA_HUMAN
Gene Name EDNRA
Synonyms
HET-AR; Endothelin-1 receptor; Endothelin receptor type A; Endothelin receptor A; ETRA; ETA-R; ETA receptor; ETA; ET-A
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Representative Drug(s) Sulfisoxazole Drug Info IC50 = 780 nM [6]
Co-Target Name Carbonic anhydrase VI (CA-VI) Successful Target
UniProt ID CAH6_HUMAN
Gene Name CA6
Synonyms
Secreted carbonic anhydrase; Salivary carbonic anhydrase; Carbonic anhydrase 6; Carbonate dehydratase VI
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Representative Drug(s) Sulfanilamide Drug Info Ki = 941 nM [7]
Co-Target Name Carbonic anhydrase IX (CA-IX) Clinical trial Target
UniProt ID CAH9_HUMAN
Gene Name CA9
Synonyms
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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Representative Drug(s) Sulfanilamide Drug Info Ki = 1.02 Ratio Click to Show More [1]
2 Sulfanilamide Drug Info Ki = 238 nM [8]
Co-Target Name Carbonic anhydrase VII (CA-VII) Patented-recorded Target
UniProt ID CAH7_HUMAN
Gene Name CA7
Synonyms
Carbonic anhydrase 7; Carbonate dehydratase VII
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Representative Drug(s) Sulfanilamide Drug Info Ki = 70 nM [9]
Co-Target Name Organic cation transporter 3 (OCT3) Literature-reported Target
UniProt ID S22A3_HUMAN
Gene Name SLC22A3
Synonyms
Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMTH
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Representative Drug(s) Chlorhexidine Drug Info IC50 = 410 nM [5]
Co-Target Name Multidrug and toxin extrusion protein 2 (MATE2) Literature-reported Target
UniProt ID S47A2_HUMAN
Gene Name SLC47A2
Synonyms
hMATE-2; Solute carrier family 47 member 2; MATE2; MATE-2; Kidney-specific H(+)/organic cation antiporter
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Representative Drug(s) Chlorhexidine Drug Info IC50 = 500 nM [5]
Co-Target Name Carbonic anhydrase XIII (CA13) Co-Target
UniProt ID CAH13_HUMAN
Gene Name CA13
Synonyms
Carbonic anhydrase 13; Carbonate dehydratase XIII; CA-XIII
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Representative Drug(s) Sulfanilamide Drug Info Ki = 32 nM [8]
Co-Target Name Solute carrier family 22 member 1 (SLC22A1) Co-Target
UniProt ID S22A1_HUMAN
Gene Name SLC22A1
Synonyms
Organic cation transporter 1; hOCT1
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Representative Drug(s) Chlorhexidine Drug Info IC50 = 210 nM [5]
Co-Target Name Solute carrier family 22 member 2 (SLC22A2) Co-Target
UniProt ID S22A2_HUMAN
Gene Name SLC22A2
Synonyms
Organic cation transporter 2; hOCT2
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Representative Drug(s) Chlorhexidine Drug Info IC50 = 400 nM [5]
Co-Target Name Carbonic anhydrase III (CA3) Co-Target
UniProt ID CAH3_HUMAN
Gene Name CA3
Synonyms
Carbonic anhydrase 3; Carbonate dehydratase III; CA-III
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Representative Drug(s) Sulfanilamide Drug Info Ki = 988 nM [8]
References  Top
REF 1 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett. 2005 May 2;15(9):2359-64.
REF 2 Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1776-9.
REF 3 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
REF 4 Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties. Bioorg Med Chem. 2014 May 15;22(10):2867-74.
REF 5 Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14;56(3):781-795.
REF 6 Selective optimization of side activities: another way for drug discovery. J Med Chem. 2004 Mar 11;47(6):1303-14.
REF 7 Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies. Bioorg Med Chem. 2014 Jan 1;22(1):334-40.
REF 8 The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. J Med Chem. 2010 Jan 28;53(2):850-4.
REF 9 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.

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