Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88975 | Target Info | |||
| Target Name | Phosphodiesterase 3A (PDE3A) | ||||
| Synonyms |
cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Phosphodiesterase 3A; Cyclic GMP-inhibited phosphodiesterase A; Cyclic GMP inhibited phosphodiesterase A; CGI-PDE A
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| Target Type | Successful Target | ||||
| Gene Name | PDE3A | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | P2Y purinoceptor 12 (P2RY12) | Successful Target | ||||
| UniProt ID | P2Y12_HUMAN | |||||
| Gene Name | P2RY12 | |||||
| Synonyms |
SP1999; P2Y12 platelet ADP receptor; P2Y12; P2Y(cyc); P2Y(ADP)P2Y purinoceptor 12; P2Y(ADP); P2Y(AC); P2T(AC); P2RY12; Nucleotide P2Y(12) receptor; Adenosine P2Y12 receptor; ADPG-R; ADP-glucose receptor
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| Representative Drug(s) | Anagrelide | Drug Info | EC50 = 1.05 PuM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. J Med Chem. 1992 Jul 10;35(14):2672-87. | ||||
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