Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90286 | Target Info | |||
| Target Name | Fusion protein FGFR3-TACC3 (FGFR3-TACC3) | ||||
| Synonyms |
FGFR3-TACC3 gene fusion; FGFR3-TACC3
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| Target Type | Clinical trial Target | ||||
| Gene Name | FGFR3-TACC3 | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Fibroblast growth factor receptor 2 (FGFR2) | Successful Target | ||||
| UniProt ID | FGFR2_HUMAN | |||||
| Gene Name | FGFR2 | |||||
| Synonyms |
Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; KSAM; KGFR; K-sam; FGFR-2; FGF-2 receptor; CD332; BEK
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| Representative Drug(s) | PD173074 | Drug Info | IC50 = 5 nM | [1] | ||
| Co-Target Name | Fibroblast growth factor receptor 1 (FGFR1) | Successful Target | ||||
| UniProt ID | FGFR1_HUMAN | |||||
| Gene Name | FGFR1 | |||||
| Synonyms |
c-fgr; bFGF-R-1; bFGF-R; N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT2; FLT-2; FLG; FGFR-1; FGFBR; CEK; CD331 antigen; CD331; Basic fibroblast growth factor receptor 1; BFGFR
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| Representative Drug(s) | PD173074 | Drug Info | IC50 = 19 nM | [2] | ||
| Co-Target Name | Vascular endothelial growth factor receptor 2 (KDR) | Successful Target | ||||
| UniProt ID | VGFR2_HUMAN | |||||
| Gene Name | KDR | |||||
| Synonyms |
VEGFR2; VEGFR-2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; Fetal liver kinase 1; FLK1; FLK-1; CD309
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| Representative Drug(s) | PD173074 | Drug Info | IC50 = 100 nM | [3] | ||
| Co-Target Name | Vascular endothelial growth factor receptor (VEGFR) | Successful Target | ||||
| UniProt ID | VGFR1_HUMAN; VGFR2_HUMAN; VGFR3_HUMAN | |||||
| Gene Name | NO-GeName | |||||
| Representative Drug(s) | PD173074 | Drug Info | IC50 = 190 nM | [2] | ||
| Co-Target Name | Fibroblast growth factor receptor (FGFR) | Clinical trial Target | ||||
| UniProt ID | FGFR1_HUMAN; FGFR2_HUMAN; FGFR3_HUMAN; FGFR4_HUMAN | |||||
| Gene Name | NO-GeName | |||||
| Synonyms |
FGF receptor
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| Representative Drug(s) | PD173074 | Drug Info | IC50 = 7 nM | [2] | ||
| Co-Target Name | Fibroblast growth factor receptor 3 (FGFR3) | Clinical trial Target | ||||
| UniProt ID | FGFR3_HUMAN | |||||
| Gene Name | FGFR3 | |||||
| Synonyms |
JTK4; FGFR-3; CD333
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| Representative Drug(s) | PD173074 | Drug Info | EC50 = 30 nM | [4] | ||
| References | Top | ||||
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| REF 1 | An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors. Eur J Med Chem. 2017 Jan 27;126:476-90. | ||||
| REF 2 | Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases. J Med Chem. 2005 Jul 14;48(14):4628-53. | ||||
| REF 3 | Discovery of Substituted 1H-Pyrazolo[3,4-b]pyridine Derivatives as Potent and Selective FGFR Kinase Inhibitors. ACS Med Chem Lett. 2016 Apr 20;7(6):629-34. | ||||
| REF 4 | Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41. | ||||
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