Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T93995 Target Info
Target Name Ubiquitin-like protein Nedd8 (NEDD8)
Synonyms
Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
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Target Type Clinical trial Target
Gene Name NEDD8
Biochemical Class Ubiquitin family
UniProt ID
NEDD8_HUMAN
Co-Targets of This Target  Top
Co-Target Name NEDD8-activating enzyme E1C (UBA3) Literature-reported Target
UniProt ID UBA3_HUMAN
Gene Name UBA3
Synonyms
Ubiquitin-like modifier-activating enzyme 3; Ubiquitin-activating enzyme E1C; Ubiquitin-activating enzyme 3; UBE1C; NEDD8-activating enzyme E1 catalytic subunit
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Representative Drug(s) MLN4924 Drug Info IC50 = 5 nM [1]
Co-Target Name Autophagy-related protein 7 (ATG7) Literature-reported Target
UniProt ID ATG7_HUMAN
Gene Name ATG7
Synonyms
hAGP7; Ubiquitin-like modifier-activating enzyme ATG7; Ubiquitin-activating enzyme E1-like protein; ATG12-activating enzyme E1 ATG7; APG7L; APG7-like
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Representative Drug(s) MLN4924 Drug Info IC50 ~ 1000 nM [2]
Co-Target Name Ubiquitin-like modifier-activating enzyme 6 (UBA6) Co-Target
UniProt ID UBA6_HUMAN
Gene Name UBA6
Synonyms
Ubiquitin-activating enzyme 6; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2
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Representative Drug(s) MLN4924 Drug Info IC50 ~ 1000 nM [2]
References  Top
REF 1 Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2680-93.
REF 2 Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem. 2018 Apr 26;61(8):3239-52.

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