Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96079 | Target Info | |||
| Target Name | C-X-C chemokine receptor type 4 (CXCR4) | ||||
| Synonyms |
Stromal cell-derived factor 1 receptor; SDF-1 receptor; NPYRL; Lipopolysaccharide-associated protein 3; Leukocyte-derived seven transmembrane domain receptor; LPS-associated protein 3; LESTR; LCR1; LAP-3; HM89; Fusin; FB22; Chemokine receptor CXCR4; CXCR-4; CXC-R4; CD184 antigen; CD184
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| Target Type | Successful Target | ||||
| Gene Name | CXCR4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | C-C chemokine receptor type 2 (CCR2) | Clinical trial Target | ||||
| UniProt ID | CCR2_HUMAN | |||||
| Gene Name | CCR2 | |||||
| Synonyms |
Monocyte chemoattractant protein 1 receptor; MCP-1-R; Chemokine receptor CCR2B; CMKBR2; CD192; CCR-2; CC-CKR-2; C-C CKR-2
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| Representative Drug(s) | Plerixafor | Drug Info | IC50 = 0.04 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem. 2007 Oct 12;282(41):30062-9. | ||||
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