Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99295 | Target Info | |||
| Target Name | Phosphatidylinositol-4-kinase alpha (PI4KA) | ||||
| Synonyms |
PtdIns-4-kinase alpha; PI4K-alpha; PI4-kinase alpha
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| Target Type | Literature-reported Target | ||||
| Gene Name | PI4KA | ||||
| Biochemical Class | PI3/PI4-kinase family. Type III PI4K subfamily | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | PI3-kinase alpha (PIK3CA) | Successful Target | ||||
| UniProt ID | PK3CA_HUMAN | |||||
| Gene Name | PIK3CA | |||||
| Synonyms |
p110alpha; Serine/threonine protein kinase PIK3CA; PtdIns3kinase subunit p110alpha; PtdIns3kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; PtdIns-3-kinase subunit alpha; Phosphoinositide3kinase catalytic alpha polypeptide; Phosphoinositide-3-kinase catalytic alpha polypeptide; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PI3kinase subunit alpha; PI3Kalpha; PI3K-alpha; PI3-kinase subunit alpha
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| Representative Drug(s) | Alpelisib | Drug Info | IC50 = 4.6 nM | [1] | ||
| Co-Target Name | PI3-kinase gamma (PIK3CG) | Successful Target | ||||
| UniProt ID | PK3CG_HUMAN | |||||
| Gene Name | PIK3CG | |||||
| Synonyms |
p120-PI3K; p110gamma; Serine/threonine protein kinase PIK3CG; PtdIns-3-kinase subunit p110-gamma; PtdIns-3-kinase subunit gamma; PtdIns-3-kinase p110; Phosphoinositol-3 kinase; Phosphoinositide-3-kinase catalytic gamma polypeptide; Phosphoinositide 3-Kinase gamma; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PI3Kgamma; PI3K-gamma; PI3K; PI3-kinase subunit gamma; PI3-kinase p110 subunit gamma
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| Representative Drug(s) | Alpelisib | Drug Info | IC50 = 250 nM | [2] | ||
| Co-Target Name | PI3-kinase delta (PIK3CD) | Successful Target | ||||
| UniProt ID | PK3CD_HUMAN | |||||
| Gene Name | PIK3CD | |||||
| Synonyms |
PtdIns-3-kinase subunit p110-delta; PtdIns-3-kinase subunit delta; Phosphoinositide 3-kinase delta; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PI3Kdelta; PI3K-delta; PI3-kinase subunit delta; PI3-kinase p110 subunit delta; P110delta
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| Representative Drug(s) | Alpelisib | Drug Info | IC50 = 290 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Class II Phosphoinositide 3-Kinases as Novel Drug Targets. J Med Chem. 2017 Jan 12;60(1):47-65. | ||||
| REF 2 | Discovery of a novel tricyclic 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kalpha inhibitor with high PI3K isoform selectivity and potent cellular activity. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3582-4. | ||||
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