COVID-19 Drug Information

Drug General Information

Drug ID

D05ULR

Drug Name

Sildenafil

Synonyms

sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; BNRNXUUZRGQAQC-UHFFFAOYSA-N; Sildenafil

Drug Type

Small molecular drug

Indication

Coronavirus Disease 2019 (COVID-19)

Phase 3

[1]

Other Indication

Erectile dysfunction

Approved

[2]

Therapeutic Class

Antiviral Agents

Structure

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2D MOL

3D MOL

Formula

C22H30N6O4S

Canonical SMILES

CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

InChI

1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)

InChIKey

BNRNXUUZRGQAQC-UHFFFAOYSA-N

CAS Number

CAS 139755-83-2

PubChem Compound ID

135398744

ChEBI ID

CHEBI:9139

Target

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Target(s)

HUMAN phosphodiesterase type 5 (PDE5)

Target Info

Inhibitor

[3], [4]

Sildenafil can increase the level of NO through PDE5 inhibiton, which further prevents the replication cycle of SARS CoV/SARS CoV-2.

References		Top
1	ClinicalTrials.gov (NCT04304313) A Pilot Study of Sildenafil in COVID-19. U.S. National Institutes of Health.
2	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 206401.
3	Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. J Virol. 2005 Feb;79(3):1966-9. doi: 10.1128/JVI.79.3.1966-1969.2005.
4	Any possible role of phosphodiesterase type 5 inhibitors in the treatment of severe COVID19 infections A lesson from urology. Clin Immunol. 2020 May;214:108414.

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Prof. Yuzong CHEN