COVID-19 Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07XRU
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| Drug Name |
Telmisartan
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| Synonyms |
Telmisartan; 144701-48-4; Micardis; Pritor; BIBR 277; Kinzalmono; BIBR-277; BIBR 277SE; Telmisattan; Targit; Telmisartan [INN]; UNII-U5SYW473RQ; BIBR-277SE; BIBR-277-SE; U5SYW473RQ; CHEMBL1017; CHEBI:9434; Telmisartan
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| Drug Type |
Small molecular drug
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| Indication | Coronavirus Disease 2019 (COVID-19) | Phase 3 | [1] | |
| Other Indication | Hypertension | Approved | [2] | |
| Therapeutic Class |
Antiviral Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C33H30N4O2
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| Canonical SMILES |
CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C
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| InChI |
1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
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| InChIKey |
RMMXLENWKUUMAY-UHFFFAOYSA-N
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| CAS Number |
CAS 144701-48-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:9434
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| Target | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN type-1 angiotensin II receptor (AGTR1) | Target Info | Blocker | [3], [4] |
| Angiotensin II drive lung injury through activating the type 1 angiotensin receptor. Telmisartan, an angiotensin II receptor blocker, prevents inflammation and fibrosis in SARS-CoV-2 infection. | ||||
| References | Top | |||
|---|---|---|---|---|
| 1 | ClinicalTrials.gov (NCT04359953) Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on the Survival of Hospitalized Elderly Patients With COVID-19. U.S. National Institutes of Health. | |||
| 2 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 203867. | |||
| 3 | Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol. 2020 Apr 3. | |||
| 4 | Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19. Drug Dev Res. 2020 May 1. | |||
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