COVID-19 Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C5SO
|
|||
| Drug Name |
RS-PPCC
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Coronavirus Disease 2019 (COVID-19) | Investigative | [1] | |
| Therapeutic Class |
Antiviral Agents
|
|||
| Target | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN opioid receptor sigma 1 (OPRS1) | Target Info | Agonist | [2] |
| RS-PPCC binds to opioid receptor sigma 1, which participates in ER stress response and thus leads to inhibition of its interaction with SARS-CoV-2 Nsp6 protein. | ||||
| References | Top | |||
|---|---|---|---|---|
| 1 | Novel sigma receptor ligands: synthesis and biological profile. J Med Chem. 2007 Mar 8;50(5):951-61. | |||
| 2 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | |||
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