COVID-19 Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D8RC
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Drug Name |
Metformin
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Synonyms |
Fortamet
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Drug Type |
Small molecular drug
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Indication | Coronavirus Disease 2019 (COVID-19) | Investigative | [1] | |
Other Indication | Type-2 diabetes | Approved | [2] | |
Therapeutic Class |
Antiviral Agents
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Structure |
Download2D MOL |
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Formula |
C4H11N5
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Canonical SMILES |
CN(C)C(=N)N=C(N)N
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InChI |
1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
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InChIKey |
XZWYZXLIPXDOLR-UHFFFAOYSA-N
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CAS Number |
CAS 657-24-9
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:6801
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Target | Top | |||
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Target(s) | HUMAN mannose receptor (MRC1) | Target Info | Inhibitor | [1] |
Direct viral-human interactions with proteins regulated by the mTORC1 pathway, such as LARP1, and FKBP7, which interact with the SARS-CoV-2 N and Orf8 proteins. Metformin, a MRC 1 inhibitor, is an indirect modulator of this protein complex. |
References | Top | |||
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1 | A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. March 2020 | |||
2 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (NDA) 212614 |
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