COVID-19 Drug Information
Drug General Information | Top | |||
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Drug ID |
D0I6RV
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Drug Name |
HR1P peptide
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Synonyms |
HR1P
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Drug Type |
Protein/peptide drug
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Indication | Middle East Respiratory Syndrome (MERS) | Preclinical | [1] | |
Therapeutic Class |
Antiviral Agents
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Target | Top | |||
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Target(s) | MERS-CoV spike glycoprotein S2 subunit (S S2) | Target Info | Inhibitor | [1] |
HR1P, spanning residues 998-1039 in HR1 of MERS-CoV spike protein S2 subunit, can form a stable six-helix bundle fusion core structure, suggesting HR1P blocks MERS-CoV entering into the host cell mainly through membrane fusion mechanism. |
References | Top | |||
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1 | Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014;5:3067. |
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