COVID-19 Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0JL1M
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| Drug Name |
Thiethylperazine
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| Synonyms |
ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (*Dimaleate*); GS-95 (*Dimaleate*)
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| Drug Type |
Small molecular drug
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| Indication | Middle East Respiratory Syndrome (MERS) | Investigative | [1] | |
| Therapeutic Class |
Antiviral Agents
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H29N3S2
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| Canonical SMILES |
CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C
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| InChI |
1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
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| InChIKey |
XCTYLCDETUVOIP-UHFFFAOYSA-N
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| CAS Number |
CAS 1420-55-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9342, 618292, 5646731, 7849413, 7980773, 8153348, 10507857, 14879091, 29224490, 46506502, 48416610, 49699402, 50006536, 56352874, 57322781, 76368511, 85209578, 103462495, 104309248, 125089234, 125823178, 127339724, 127339725, 127339726, 134222490, 134337627, 134979014, 135739860, 137001505, 142971091, 160963719, 162939803, 178103879, 179116916, 184527123, 198985013, 226432954, 249932754, 251971089, 252655192
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| ChEBI ID |
CHEBI:9544
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| Target | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN clathrin-mediated endocytosis (RME) | Target Info | Inhibitor | [1] |
| Thiethylperazine exhibits inhibitory activity against clathrin-mediated endocytosis of MERS-CoV with EC50s of 7.86 microM. | ||||
| References | Top | |||
|---|---|---|---|---|
| 1 | Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93. | |||
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