Target Information
| Target General Infomation | Top | ||||
|---|---|---|---|---|---|
| Target ID |
T86573
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| Target Name |
HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
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| Synonyms |
IMPDH-II; IMPDH 2; IMPD2; IMPD 2; IMP dehydrogenase 2
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| Gene Name |
IMPDH2
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| Target Status |
Literature-reported Target
|
[1] | |||
| Disease | [+] 1 Target-related Diseases | + | |||
| 1 | COVID-19 [ICD-11: 1D6Y] | ||||
| Function |
Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
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| BioChemical Class |
CH-OH donor oxidoreductase
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| UniProt ID | |||||
| EC Number |
EC 1.1.1.205
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| Sequence |
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF |
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| Drugs and Modes of Action | Top | ||||
|---|---|---|---|---|---|
| Investigative agents | [+] 2 Investigative agents | + | |||
| 1 | Merimepodib | Drug Info | Investigative | COVID-19 | [1] |
| 2 | Ribavirin | Drug Info | Investigative | COVID-19 | [2] |
| Mode of Action | [+] 1 Modes of Action | + | |||
| Inhibitor | [+] 2 Inhibitor drugs | + | |||
| 1 | Ribavirin | Drug Info | [2] | ||
| 2 | Merimepodib | Drug Info | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| 1 | The IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro. April 09, 2020. doi: https://doi.org/10.1101/2020.04.07.028589 | ||||
| 2 | Proteomics of SARS-CoV-2-infected Host Cells Reveals Therapy Targets. Nature. 2020 May 14. doi: 10.1038/s41586-020-2332-7. | ||||
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