Resistance mutation info of drug
| Drug General Information | |||||||||||
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| Drug ID | D00HYK | ||||||||||
| Drug Name | AFN-1252 | ||||||||||
| Synonyms | API-1252; API-1401; Antibacterial therapeutics, Affinium; Antibacterials, Affinium; Bacterial fatty acid biosynthesis inhibitors, Affinium; Galapagos program, Affinium; Antibacterial therapeutics, Affinium/GSK; Antibacterials, Affinium/GSK; FabI inhibitors (antibacterial), Affinium; AFN-1252 (oral, bacterial infection); AFN-1252 (oral, bacterial infection), Affinium | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Company | Affinium pharmaceuticals | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Bacterial Staphylococcus aureus Enoyl ACP reductase (fabI) | Target Info | |||||||||
| Gene Name | fabI | ||||||||||
| Uniprot ID | FABI_STAA8 | ||||||||||
| Species | Staphylococcus aureus | ||||||||||
| Reference Sequence |
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP DNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG VTGENIHVDSGFHAIK [Staphylococcus aureus] |
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| Targeted Disease | Staphylococcal infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. | ||||||||||
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