Resistance mutation info of drug
| Drug General Information | ||||||||||||||||
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| Drug ID | D01RXW | |||||||||||||||
| Drug Name | Vaniprevir | |||||||||||||||
| Synonyms | Vaniprevir; UNII-CV3X74AO1H; MK-7009; MK7009; 923590-37-8; CV3X74AO1H; Vaniprevir [USAN:INN]; vanihep; 3su6; SCHEMBL3264200; BDBM103836; BCP09841; ZINC95627836; AKOS030527003; SB16734; DB11929; CS-0340; NCGC00485973-01; HY-10243; Cyclopropanecarboxamide, N-(((6-(2-carboxy-2,3-dihydro-1H-isoindol-4-yl)-2,2-dimethylhexyl)oxy)carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethyl-, (1-2)-lactone, (1R,2R)- | |||||||||||||||
| Drug Type | Small molecular drug | |||||||||||||||
| Company | Merck | |||||||||||||||
| Structure |
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| Drug Resistance Mutations | ||||||||||||||||
| Target Name | HCV Serine protease (NS3) | Target Info | ||||||||||||||
| Gene Name | NS3 | |||||||||||||||
| Uniprot ID | POLG_HCVJA(1027-1657) | |||||||||||||||
| Species | Hepatitis C virus genotype 1b | |||||||||||||||
| Reference Sequence |
APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWTVYHGAG SKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVVPVRRRG DSRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESMETTMR SPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA YMSKAHGIEPNIRTGVRTITTGGPITYSTYCKFLADGGCSGGAYDIIICDECHSTDSTTI LGIGTVLDQAETAGARLVVLATATPPGSITVPHPNIEEVALSNTGEIPFYGKAIPIEAIK GGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGFTG DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRAQRRGRTGRGRSGIYRFVTPGE RPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLT HIDAHFLSQTKQAGDNLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY RLGAVQNEVTLTHPITKYIMACMSADLEVVT [Hepatitis C virus genotype 1b] |
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| Targeted Disease | HCV infection | |||||||||||||||
| Drug Resistance Mutations |
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| References | ||||||||||||||||
| REF 1 | MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11. | |||||||||||||||
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