Drug General Information
Drug ID	D03JRA
Drug Name	Beta-lactam
Structure
Drug Resistance Mutations
Target Name	Bacterial Penicillin-binding protein 2B (PBP2)				Target Info
Gene Name	PBP2
Uniprot ID	PBP2_NEIMB
Species	Neisseria meningitidis
Reference Sequence	MLIKSEYKPRMLPKEEQVKKPMTSNGRISFVLMAIAVLFAGLIARGLYLQTVTYNFLKEQ GDNRIVRTQTLPATRGTVSDRNGAVLALSAPTESLFAVPKEMKEMPSAAQLERLSELVDV PVDVLRNKLEQKGKSFIWIKRQLDPKVAEEVKALGLENFVFEKELKRHYPMGNLFAHVIG FTDIDGKGQEGLELSLEDSLHGEDGAEVVLRDRQGNIVDSLDSPRNKAPKNGKDIILSLD QRIQTLAYEELNKAVEYHQAKAGTVVVLDARTGEILALANTPAYDPNRPGRADSEQRRNR AVTDMIEPGSAIKPFVIAKALDAGKTDLNERLNTQPYKIGPSPVRDTHVYPSLDVRGIMQ KSSNVGTSKLSARFGAEEMYDFYHELGIGVRMHSGFPGETAGLLRNWRRWRPIEQATMSF GYGLQLSLLQLARAYTALTHDGVLLPVSFEKQAVAPQGKRIFKESTAREVRNLMVSVTEP GGTGTAGAVDGFDVGAKTGTARKFVNGRYADNKHIATFIGFAPAKNPRVIVAVTIDEPTA HGYYGGVVAGPPFKKIMGGSLNILGISPTKPLTAAAVKTPS [Neisseria meningi tidis]
Targeted Disease	Meningococcal disease
Drug Resistance Mutations	Mutation info Missense: A501P [1]
	Mutation info Missense: A510V [1]
	Mutation info Missense: F504L [1]
	Mutation info Missense: G482S [1]
	Mutation info Missense: G545S [1]
	Mutation info Missense: I312M [1]
	Mutation info Missense: N512Y [1]
	Mutation info Missense: V316T [1]
References
REF 1	The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.