Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D03UVS | ||||||||||
| Drug Name | Gemcitabine | ||||||||||
| Synonyms | Gemcitabine hydrochloride; DDFC; DFdC; DFdCyd; Folfugem; GEO; Gamcitabine; GemLip; Gemcel; Gemcin; Gemcitabina; Gemcitabinum; Gemtro; Gemzar; Zefei; Gemcitabine HCl; Gemcitabine stereoisomer; LY 188011; LY188011; Gemcitabina [INN-Spanish]; Gemcitabinum [INN-Latin]; Gemzar (TN); Gemzar (hydrochloride); Inno-D07001; LY-188011; Gemcitabine (USAN/INN) | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Therapeutic Class | Anticancer Agents | ||||||||||
| Company | Eli Lilly | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Deoxycytidine kinase (DCK) | Target Info | |||||||||
| Gene Name | DCK | ||||||||||
| Uniprot ID | DCK_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE DFKDKYESLVEKVKEFLSTL [Homo sapiens] |
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| Targeted Disease | Gastric cancer | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.Biochem Biophys Res Commun.2015 Sep 4;464(4):1084-9. | ||||||||||
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