Drug General Information
Drug ID	D05HPI
Drug Name	Daptomycin
Synonyms	Cidecin; Cubicin; Dapcin; Daptomicina; Daptomycine; Daptomycinum; Deptomycin; Daptomicina [Spanish]; Daptomycine [French]; Daptomycinum [Latin]; LY146032; Cubicin (TN); LY-146032; MK-3009; Daptomycin [USAN:INN:BAN]; Daptomycin (JAN/USAN/INN); N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone; N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone; N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
Drug Type	Small molecular drug
Therapeutic Class	Antibiotics
Company	Cubist Pharmaceuticals
Structure
Drug Resistance Mutations
Target Name	Bacterial DNA-directed RNA polymerase subunit beta (rpoB)				Target Info
Gene Name	rpoB
Uniprot ID	RPOB_MYCTU
Species	Mycobacterium tuberculosis
Reference Sequence	MLEGCILADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDS FEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVD ECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLV RSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKA LGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLF FKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGG VEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINI RPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHY GRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHV VAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHD DANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITV MHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLL VAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEV LADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVP HGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILP VEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLP DELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFP YPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYG AAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSS DGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA [Mycobacterium tuberc ulosis]
Targeted Disease	Enterococcal infection; Staphylococcal infection
Drug Resistance Mutations	Mutation info Missense: A1085V [1]
	Mutation info Missense: A621E [1]
	Mutation info Missense: F632S [1]
	Mutation info Missense: I953S [1]
	Mutation info Missense: Q961K [1]
Target Name	Bacterial Cardiolipin synthase (cls)				Target Info
Gene Name	cls
Uniprot ID	CLS_STAAN
Species	Staphylococcus aureus
Reference Sequence	MIELLSIALKHSNIILNSIFIGAFILNLLFAFTIIFMERRSANSIWAWLLVLVFLPLFGF ILYLLLGRQIQRDQIFKIDKEDKKGLELIVDEQLAALKNENFSNSNYQIVKFKEMIQMLL YNNAAFLTTDNDLKIYTDGQEKFDDLIQDIRNATDYIHFQYYIIQNDELGRTILNELGKK AEQGVEVKILYDDMGSRGLRKKGLRPFRNKGGHAEAFFPSKLPLINLRMNNRNHRKIVVI DGQIGYVGGFNVGDEYLGKSKKFGYWRDTHLRIVGDAVNALQLRFILDWNSQATRDHISY DDRYFPDVNSGGTIGVQIASSGPDEEWEQIKYGYLKMISSAKKSIYIQSPYFIPDQAFLD SIKIAALGGVDVNIMIPNKPDHPFVFWATLKNAASLLDAGVKVFHYDNGFLHSKTLVIDD EIASVGTANMDHRSFTLNFEVNAFIYDQQIAKKLKQAFIDDLAVSSELTKARYAKRSLWI KFKEGISQLLSPIL [Staphylococcus aureus]
Targeted Disease	Enterococcal infection; Staphylococcal infection
Drug Resistance Mutations	Mutation info Missense: A23V [1]
	Mutation info Missense: F60S [1]
	Mutation info Missense: L52F [1]
	Mutation info Missense: T33N [1]
	Mutation info Missense: H215R [3]
	Mutation info Missense: R218Q [3]
Target Name	Bacterial CDP-diacylglycerol--glycerol-3-phosphate (pgsA)				Target Info
Gene Name	pgsA
Uniprot ID	PGSA_STAAN
Species	Staphylococcus aureus
Reference Sequence	MNIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFILASLSDFVD GYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNSVVAIIIIAREFAVTGLRLL QIEQGFVSAAGQLGKIKTAVTMVAITWLLLGDPLATLIGLSLGQILLYIGVIFTILSGIE YFYKGRDVFKQK [Staphylococcus aureus]
Targeted Disease	Enterococcal infection; Staphylococcal infection
Drug Resistance Mutations	Mutation info Missense: A64V [1]
	Mutation info Missense: K66R [1]
	Mutation info Missense: S177F [1]
	Mutation info Missense: V59N [1]
Target Name	Bacterial Phosphatidylglycerol (mprF)				Target Info
Gene Name	mprF
Uniprot ID	MPRF_STAAN
Species	Staphylococcus aureus
Reference Sequence	MNQEVKNKIFSILKITFATALFIFVAITLYRELSGINFKDTLVEFSKINRMSLVLLFIGG GASLVILSMYDVILSRALKMDISLGKVLRVSYIINALNAIVGFGGFIGAGVRAMVYKNYT HDKKKLVHFISLILISMLTGLSLLSLLIVFHVFDASLILDKITWVRWVLYVVSFFLPLFI IYSMVRPPDKNNRFVGLYCTLVSCVEWLAAAVVLYFCGVIVDAHVSFMSFIAIFIIAALS GLVSFIPGGFGAFDLVVLLGFKTLGVPEEKVLLMLLLYRFAYYFVPVIIALILSSFEFGT SAKKYIEGSKYFIPAKDVTSFLMSYQKDIIAKIPSLSLAILVFFTSMIFFVNNLTIVYDA LYDGNHLTYYILLAIHTSACLLLLLNVVGIYKQSRRAIIFAMISILLITVATFFTYASYI LITWLAIIFVLLIVAFRRARRLKRPVRMRNIVAMLLFSLFILYVNHIFIAGTLYALDIYT IEMHTSVLRYYFWLTILIIAIIIGMIAWLFDYQFSKVRISSKIEDCEEIINQYGGNYLSH LIYSGDKQFFTNENKTAFLMYRYKASSLVVLGDPLGDENAFDELLEAFYNYAEYLGYDVI FYQVTDQHMPLYHNFGNQFFKLGEEAIIDLTQFSTSGKKRRGFRATLNKFDELNISFEII EPPFSTEFINELQHVSDLWLDNRQEMHFSVGQFNEEYLSKAPIGVMRNEENEVIAFCSLM PTYFNDAISVDLIRWLPELDLPLMDGLYLHMLLWSKEQGYTKFNMGMATLSNVGQLHYSY LRERLAGRVFEHFNGLYRFQGLRRYKSKYNPNWEPRFLVYRKDNSLWESLSKVMRVIRHK [Staphylococcus aureus]
Targeted Disease	Enterococcal infection; Staphylococcal infection
Drug Resistance Mutations	Mutation info Missense: F57S [1]
	Mutation info Missense: G61V [1]
	Mutation info Missense: I420N [1]
	Mutation info Missense: L341S [1]
	Mutation info Missense: L826F [1]
	Mutation info Missense: M347R [1]
	Mutation info Missense: P314L [1]
	Mutation info Missense: S295L [1]
	Mutation info Missense: S337L [1]
	Mutation info Missense: T345A [1]
	Mutation info Missense: T345I [1]
	Mutation info Missense: T345K [1]
	Mutation info Missense: T472K [1]
	Mutation info Missense: V351E [1]
Target Name	Bacterial Sensor histidine kinase (liaS)				Target Info
Gene Name	liaS
Uniprot ID	A0A1B1EYN7_ENTFC
Species	Enterococcus faecium
Reference Sequence	MMGKISRAMLAVYSGIAAFLIILFSLFTYFYASNQSHWWGELLRARLLYVPLIFHLLAIS LGVGLIVFLLLSLIQKTKYGKIEEKLRALSSDNYESKLLLLPIPSASDDLYIKDIDKEIT KIKEKMIEVSSELQIVTSRPQYVDGQTKEEILELERHRLARELHDSVSQQLFAAMMMMSA LTEQAEKSETPEMFRKQLKMVAEIINASQSEMRALLLHLRPVNLEEKSLKQGIEQLLKEL QNKIQISLKWDVEDVKLSSSIEDHLFRIVQELLSNTLRHAKANELEVYLHKIDNNLLLRI IDDGTGFNMNETKTGSYGLNNIKERVAGIGGTVKIISFKGQGTSVEIKVPLMKEA [Ent erococcus faecium]
Targeted Disease	Enterococcal infection; Staphylococcal infection
Drug Resistance Mutations	Mutation info Missense: A180T [2]
	Mutation info Missense: E192G [2]
	Mutation info Missense: H264Q [2]
	Mutation info Missense: T120A [2]
References
REF 1	The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57.
REF 2	CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573.
REF 3	Biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci.Antimicrob Agents Chemother.2013 Jan;57(1):289-96.

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