Resistance mutation info of drug
| Drug General Information | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D08ANZ | |||||||||||||||
| Drug Name | Pembrolizumab | |||||||||||||||
| Drug Type | Monoclonal antibody | |||||||||||||||
| Company | Merck Kenilworth, NJ | |||||||||||||||
| Drug Resistance Mutations | ||||||||||||||||
| Target Name | GTPase Nras (NRAS) | Target Info | ||||||||||||||
| Gene Name | NRAS | |||||||||||||||
| Uniprot ID | RASN_HUMAN | |||||||||||||||
| Species | Homo sapiens | |||||||||||||||
| Reference Sequence |
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG CMGLPCVVM [Homo sapiens] |
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| Targeted Disease | Skin cancer | |||||||||||||||
| Drug Resistance Mutations |
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| References | ||||||||||||||||
| REF 1 | Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget. 2015 Dec 8;6(39):42008-18. | |||||||||||||||
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