Drug General Information
Drug ID D09SGV
Drug Name Daclatasvir
Synonyms 1009119-64-5; Daclatasvir (BMS-790052); 1214735-16-6; CHEBI:82977; C40H50N8O6; methyl N-[(1S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate; Daclatasvir (USAN); cc-39; Daclatasvir BMS 790052; MLS006011140; SCHEMBL2756027; CHEMBL2023898; SCHEMBL17897804; KS-00000XPC; EX-A410
Drug Type Small molecular drug
Company Bristol-Myers Squibb
Structure D09SGV
Drug Resistance Mutations
Target Name HCV Non-structural protein 5A (NS5A) Target Info
Gene Name NS5A
Uniprot ID POLG_HCV1(1973-2420)
Species Hepatitis C virus genotype 1a
Reference Sequence SGSWLRDIWDWICEVLSDFKTWLKAKLMPQLPGIPFVSCQRGYKGVWRVDGIMHTRCHCG
AEITGHVKNGTMRIVGPRTCRNMWSGTFPINAYTTGPCTPLPAPNYTFALWRVSAEEYVE
IRQVGDFHYVTGMTTDNLKCPCQVPSPEFFTELDGVRLHRFAPPCKPLLREEVSFRVGLH
EYPVGSQLPCEPEPDVAVLTSMLTDPSHITAEAAGRRLARGSPPSVASSSASQLSAPSLK
ATCTANHDSPDAELIEANLLWRQEMGGNITRVESENKVVILDSFDPLVAEEDEREISVPA
EILRKSRRFAQALPVWARPDYNPPLVETWKKPDYEPPVVHGCPLPPPKSPPVPPPRKKRT
VVLTESTLSTALAELATRSFGSSSTSGITGDNTTTSSEPAPSGCPPDSDAESYSSMPPLE
GEPGDPDLSDGSWSTVSSEANAEDVVCC [Hepatitis C virus genotype 1a]
Targeted Disease HCV infection
Drug Resistance Mutations
Mutation info Missense: L31M [1], [2]
Level of Resistance Confer 3350 fold resistance
Mutation info Missense: L31V + Y93H [1], [2]
Level of Resistance Confer 8336 fold resistance
Mutation info Missense: L31V [1], [2]
Level of Resistance Confer 233 fold resistance
Mutation info Missense: M28T + Q30H [1], [2]
Level of Resistance Confer 8336 fold resistance
Mutation info Missense: M28T [1], [2]
Level of Resistance Confer 683 fold resistance
Mutation info Missense: P32L [1], [2]
Level of Resistance Confer 1850 fold resistance
Mutation info Missense: Q30E [1], [2]
Level of Resistance Confer 24933 fold resistance
Mutation info Missense: Q30H [1], [2]
Level of Resistance Confer 1450 fold resistance
Mutation info Missense: Q30R [1], [2]
Level of Resistance Confer 1217 fold resistance
Mutation info Missense: Y93C [1], [2]
Level of Resistance Confer 5367 fold resistance
Mutation info Missense: Y93H [1], [2]
Level of Resistance Confer 47477 fold resistance
Mutation info Missense: Y93N [1], [2]
Level of Resistance Confer 103767 fold resistance
References
REF 1 Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294):96-100.
REF 2 Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother. 2010 Sep;54(9):3641-50.

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