Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0A3ZU | ||||||||||
| Drug Name | Pomalidomide | ||||||||||
| Synonyms | Actimid (TN); Pomalidomide (Immunomodulator) | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Company | Celgene | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Protein cereblon (CRBN) | Target Info | |||||||||
| Gene Name | CRBN | ||||||||||
| Uniprot ID | CRBN_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS ALLPTIPDTEDEISPDKVILCL [Homo sapiens] |
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| Targeted Disease | Myeloma | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease. Br J Haematol. 2013 Jun;161(5):748-51. | ||||||||||
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