Drug General Information
Drug ID D0C1QS
Drug Name Iprodione
Synonyms IPRODIONE; 36734-19-7; Rovral; Glycophene; Glycophen; Promidione; Iprodial; Verisan; Kidan; Rovral flo; Rovral PM; Rovrol; Anfor; Rovral 50WP; Chipco 26019; 3-(3,5-Dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide; NRC 910; LFA 2043; Iprodione [ANSI:BSI:ISO]; 3-(3,5-Dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide; Caswell No. 470A; Iprodine; ROP 500 F; MRC 910; UNII-S3AYV2A6EU; 26019 rp; RP 26019; FA 2071; 1-Imidazolidinecarboxamide, 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-; HSDB 6855
Drug Type Small molecular drug
Structure D0C1QS
Drug Resistance Mutations
Target Name Fungal 3-ketosteroid reductase (erg27) Target Info
Gene Name erg27
Uniprot ID K0H656_BOTFU
Species Botrytis cinerea
Reference Sequence MGLPPWETSESQTFALITGANSGLGFAIASRLIDEFLTSSDTPPTKHLILILCTRTPLKT
RFTISRLRAHLRKLADYSEFATSHRAKAKSQGNVYRWQDTVARVHFLGVEVDLCDLKSVY
ALTDRLVNGTVGSPDATTMDGLRLPDGSPGTATYSADVKQDRWALSQKEGSEGELRSWGW
GLSGIRIPRLDVVVLNAGIGGWSGIDWPKAIWTVITDMTEAVTWPTYKLAEIGVITKPQL
SSASSKQAKPSDDEAAQPLLDGESPEEPPLGATFCSNVFGHYVLAHELMPLLSRTASPSA
TTSGRIIWVSSIEAQAQHFDEDDLQGLESRTPYESSKRLTDVLVLSRKLRAAGQASSSWF
DCSDVRVENSKSEEEPAAKLIRPKMYVVQPGIFVSEIMPLNFVLVFIYRLISYLVRWMGS
QWHTIKPYTAAVAPVWVALSPDDVLDNMDGAASKWGSATDASGKERVIRTEVPGWGWEGK
TPKTIDTGERRKGRQRNAEPLTREAREDFEVLGVKCWTEMENLRKEWEGLLKVKK [Bot
rytis cinerea]
Drug Resistance Mutations
Mutation info Missense: F412S [1]
Mutation info Missense: T63I [1]
Target Name Fungal Two-component osmosensing histidine-kinase (bos1) Target Info
Gene Name bos1
Uniprot ID Q8X1E7_BOTFU
Species Botrytis cinerea
Reference Sequence MEDSTIAHTTAILQTLALSSIDLPLTNVYGNKGIRLPGADTAEKLALERELAALVSRVQR
LEARAITVNNQTLPDTPNELGAPSAFADVLTGAPSRASKSTTSRQQLVNSLLAAREAPTG
GERPPKFTKLSDEELEALREHVDHQSKQLDSQKSELAGVHAQLFEQKQRQEQALNVLEVE
RVAALERELKKHQQANEAFQKALREIGEIVTAVARGDLSKKVQIHSVEMDPEITTFKRVI
NTMMDQLQIFSSEVSRVAREVGTEGILGGQAKISGVDGTWKELTDNVNVMAQNLTDQVRE
IASVTTAVAHGDLTQKIERPAQGEILQLQQTINTMVDQLRTFAAEVTRVARDVGTEGILG
GQAEIEGVQGMWNTLIVNVNAMANNLTTQVRDIAIVTTAVAKGDLTQKVQAECKGEIKQL
KETINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTT
QVREIAKVTTAVARGDLTKKIEVEVQGEIASLKDTINTMVDRLSTFAFEVSKVAREVGTD
GTLGGQAQVDNVEGKWKDLTENVNTMARNLTTQVRGISTVTQAIANGDMSQKIEVAAAGE
ILILKETINNMVDRLSIFSNEVQRVAKDVGVDGKMGGQADVAGIGGRWKEITTDVNTMAN
NLTTQVRAFGDITNAATDGDFTKLITVEASGEMDELKRKINQMVYNLRDSIQRNTLAREA
AEFANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVHNLANSLLTII
DDILDLSKIEANRMIMEEIPYTLRGTVFNALKTLAVKANEKFLDLTYRVDSSVPDHVVGD
SFRLRQVILNLVGNAIKFTEHGEVSLTIQKAEQDHCAPNEYAVEFCVSDTGIGIQADKLN
LIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMRGDVWVKSQYGKGSSFYFTCTVRLAT
SDISFIQKQLKPYQGHNVLFIDKGQTGHGKEIITMLTQLGLVPVVVDSEQHTILLGNGRT
KEKIASTYDVIVVDSIESARKLRSIDEFKYIPIVLLAPVIHVSLKSALDLGITSYMTTPC
LTIDLGNGMIPALENRAAPSLADNTKSFDILLAEDNIVNQRLAVKILEKYHHVVTVVGNG
QEALDAIKEKRYDVILMDVQMPIMGGFEATAKIREYERSLGTQRTPIIALTAHAMLGDRE
KCIQAQMDEYLSKPLKQNHLIQTILKCATLGGALLEKGREVRQSANEESPNSQNGPRGTQ
HPASSPTPAHMRPAIEPRAYTTTGPINHGSAESPSLVTADAEDPLARLLMRAHSS [Bot
rytis cinerea]
Drug Resistance Mutations
Mutation info Missense: I365N [1]
Mutation info Missense: I365S [1]
Target Name Fungal Cytochrome b (cytb) Target Info
Gene Name cytb
Uniprot ID Q18ND9_BOTFU
Species Botrytis cinerea
Reference Sequence MRIFKSHPLLKLVNSYMIDSPQPSNLSYLWNFGSLLAVCLVIQIITGVTLAMHYNPSVLE
AFNSVEHIMRDVNNGWLIRYLHSNTASAFFFIVYLHIGRGLYYGSYRAPRTLVWTIGVVI
FILMIVTAFLGYVLPYGQMSLWGATVITNLMSAVPWIGQDIVEFLWGGFSVNNATLNRFF
ALHFVLPFVLAALALMHLIALHDSAGSGNPLGISGNYDRLAFAPYFLFKDLITIFLFIII
LSIFVFFMPNVLGDSDNYIMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMLSAI
LILLAMPFTDLSRSRGIQFRPLSKIAFYIFIANFLILMVLGAKHVESPYIEFGQISTVIY
FAHFLIIVPFISLLENSLVELAVLTKEKPSR [Botrytis cinerea]
Drug Resistance Mutations
Mutation info Missense: G143A [1]
Target Name Fungal Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb) Target Info
Gene Name sdhb
Uniprot ID Q3ZMH5_BOTFU
Species Botrytis cinerea
Reference Sequence MAALRTGARSARAIFAASRPAFRTQMRTMASVDSSVPESPTVSPSRPVESASKTSTVKEP
AADSESLIKTFNIYRWNPDEPTSKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRR
SCREGICGSCAMNIDGVNTLACLCRIPRDAKHETKIYPLPHTYVVKDIVPDLTQFYKQYK
SIKPYLQHTDPAPEGKEYLQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAIL
LQSYRWLADSRDQKKEERKAALDNSMSLYRCHTILNCSRTCPKGLNPGLAIAEIKKEMAF
[Botrytis cinerea]
Drug Resistance Mutations
Mutation info Missense: H272R [1]
Mutation info Missense: H272Y [1]
Target Name Fungal Tubulin beta chain (tubA) Target Info
Gene Name tubA
Uniprot ID TBB_BOTFU
Species Botrytis cinerea
Reference Sequence MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYV
PRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVV
RREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVV
EPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCL
RFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMM
AASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRG
LKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDASISEGEEEYEEEVPIEGEE [Botrytis cinerea]
Drug Resistance Mutations
Mutation info Missense: E198A [1]
Mutation info Missense: F200Y [1]
References
REF 1 Independent Emergence of Resistance to Seven Chemical Classes of Fungicides in Botrytis cinerea.Phytopathology.2015 Apr;105(4):424-32.

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