Resistance mutation info of drug
| Drug General Information | |||||||||||
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| Drug ID | D0C1QS | ||||||||||
| Drug Name | Iprodione | ||||||||||
| Synonyms | IPRODIONE; 36734-19-7; Rovral; Glycophene; Glycophen; Promidione; Iprodial; Verisan; Kidan; Rovral flo; Rovral PM; Rovrol; Anfor; Rovral 50WP; Chipco 26019; 3-(3,5-Dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide; NRC 910; LFA 2043; Iprodione [ANSI:BSI:ISO]; 3-(3,5-Dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide; Caswell No. 470A; Iprodine; ROP 500 F; MRC 910; UNII-S3AYV2A6EU; 26019 rp; RP 26019; FA 2071; 1-Imidazolidinecarboxamide, 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-; HSDB 6855 | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Fungal 3-ketosteroid reductase (erg27) | Target Info | |||||||||
| Gene Name | erg27 | ||||||||||
| Uniprot ID | K0H656_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MGLPPWETSESQTFALITGANSGLGFAIASRLIDEFLTSSDTPPTKHLILILCTRTPLKT RFTISRLRAHLRKLADYSEFATSHRAKAKSQGNVYRWQDTVARVHFLGVEVDLCDLKSVY ALTDRLVNGTVGSPDATTMDGLRLPDGSPGTATYSADVKQDRWALSQKEGSEGELRSWGW GLSGIRIPRLDVVVLNAGIGGWSGIDWPKAIWTVITDMTEAVTWPTYKLAEIGVITKPQL SSASSKQAKPSDDEAAQPLLDGESPEEPPLGATFCSNVFGHYVLAHELMPLLSRTASPSA TTSGRIIWVSSIEAQAQHFDEDDLQGLESRTPYESSKRLTDVLVLSRKLRAAGQASSSWF DCSDVRVENSKSEEEPAAKLIRPKMYVVQPGIFVSEIMPLNFVLVFIYRLISYLVRWMGS QWHTIKPYTAAVAPVWVALSPDDVLDNMDGAASKWGSATDASGKERVIRTEVPGWGWEGK TPKTIDTGERRKGRQRNAEPLTREAREDFEVLGVKCWTEMENLRKEWEGLLKVKK [Bot rytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Two-component osmosensing histidine-kinase (bos1) | Target Info | |||||||||
| Gene Name | bos1 | ||||||||||
| Uniprot ID | Q8X1E7_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MEDSTIAHTTAILQTLALSSIDLPLTNVYGNKGIRLPGADTAEKLALERELAALVSRVQR LEARAITVNNQTLPDTPNELGAPSAFADVLTGAPSRASKSTTSRQQLVNSLLAAREAPTG GERPPKFTKLSDEELEALREHVDHQSKQLDSQKSELAGVHAQLFEQKQRQEQALNVLEVE RVAALERELKKHQQANEAFQKALREIGEIVTAVARGDLSKKVQIHSVEMDPEITTFKRVI NTMMDQLQIFSSEVSRVAREVGTEGILGGQAKISGVDGTWKELTDNVNVMAQNLTDQVRE IASVTTAVAHGDLTQKIERPAQGEILQLQQTINTMVDQLRTFAAEVTRVARDVGTEGILG GQAEIEGVQGMWNTLIVNVNAMANNLTTQVRDIAIVTTAVAKGDLTQKVQAECKGEIKQL KETINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTT QVREIAKVTTAVARGDLTKKIEVEVQGEIASLKDTINTMVDRLSTFAFEVSKVAREVGTD GTLGGQAQVDNVEGKWKDLTENVNTMARNLTTQVRGISTVTQAIANGDMSQKIEVAAAGE ILILKETINNMVDRLSIFSNEVQRVAKDVGVDGKMGGQADVAGIGGRWKEITTDVNTMAN NLTTQVRAFGDITNAATDGDFTKLITVEASGEMDELKRKINQMVYNLRDSIQRNTLAREA AEFANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVHNLANSLLTII DDILDLSKIEANRMIMEEIPYTLRGTVFNALKTLAVKANEKFLDLTYRVDSSVPDHVVGD SFRLRQVILNLVGNAIKFTEHGEVSLTIQKAEQDHCAPNEYAVEFCVSDTGIGIQADKLN LIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMRGDVWVKSQYGKGSSFYFTCTVRLAT SDISFIQKQLKPYQGHNVLFIDKGQTGHGKEIITMLTQLGLVPVVVDSEQHTILLGNGRT KEKIASTYDVIVVDSIESARKLRSIDEFKYIPIVLLAPVIHVSLKSALDLGITSYMTTPC LTIDLGNGMIPALENRAAPSLADNTKSFDILLAEDNIVNQRLAVKILEKYHHVVTVVGNG QEALDAIKEKRYDVILMDVQMPIMGGFEATAKIREYERSLGTQRTPIIALTAHAMLGDRE KCIQAQMDEYLSKPLKQNHLIQTILKCATLGGALLEKGREVRQSANEESPNSQNGPRGTQ HPASSPTPAHMRPAIEPRAYTTTGPINHGSAESPSLVTADAEDPLARLLMRAHSS [Bot rytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Cytochrome b (cytb) | Target Info | |||||||||
| Gene Name | cytb | ||||||||||
| Uniprot ID | Q18ND9_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MRIFKSHPLLKLVNSYMIDSPQPSNLSYLWNFGSLLAVCLVIQIITGVTLAMHYNPSVLE AFNSVEHIMRDVNNGWLIRYLHSNTASAFFFIVYLHIGRGLYYGSYRAPRTLVWTIGVVI FILMIVTAFLGYVLPYGQMSLWGATVITNLMSAVPWIGQDIVEFLWGGFSVNNATLNRFF ALHFVLPFVLAALALMHLIALHDSAGSGNPLGISGNYDRLAFAPYFLFKDLITIFLFIII LSIFVFFMPNVLGDSDNYIMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMLSAI LILLAMPFTDLSRSRGIQFRPLSKIAFYIFIANFLILMVLGAKHVESPYIEFGQISTVIY FAHFLIIVPFISLLENSLVELAVLTKEKPSR [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb) | Target Info | |||||||||
| Gene Name | sdhb | ||||||||||
| Uniprot ID | Q3ZMH5_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MAALRTGARSARAIFAASRPAFRTQMRTMASVDSSVPESPTVSPSRPVESASKTSTVKEP AADSESLIKTFNIYRWNPDEPTSKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRR SCREGICGSCAMNIDGVNTLACLCRIPRDAKHETKIYPLPHTYVVKDIVPDLTQFYKQYK SIKPYLQHTDPAPEGKEYLQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAIL LQSYRWLADSRDQKKEERKAALDNSMSLYRCHTILNCSRTCPKGLNPGLAIAEIKKEMAF [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Tubulin beta chain (tubA) | Target Info | |||||||||
| Gene Name | tubA | ||||||||||
| Uniprot ID | TBB_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYV PRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVV RREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVV EPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCL RFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMM AASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRG LKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDASISEGEEEYEEEVPIEGEE [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Independent Emergence of Resistance to Seven Chemical Classes of Fungicides in Botrytis cinerea.Phytopathology.2015 Apr;105(4):424-32. | ||||||||||
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