Resistance mutation info of drug
| Drug General Information | |||||||||||
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| Drug ID | D0G1WV | ||||||||||
| Drug Name | Thiophanate-methyl | ||||||||||
| Synonyms | Thiophanate-methyl; 23564-05-8; Thiophanate M; THIOPHANATE METHYL; Methylthiofanate; Methylthiophanate; Neotopsin; Mildothane; Fungo; Cercobin methyl; Methyl topsin; Topsin Methyl; Methyl thiophanate; Metoben; Caligran; Thiopan; Cycosin; Easout; Enovit methyl; Enovit Super; Cercobin M; Topsin M; Enovit M; Sipcavit; Sipcaplant; Sipcasan; Trevin; Ditek; Rilon; Topsin NF-44; Topsin wp methyl; Pelt 14; Fungo 50; NF 44; Tiofanate metile; Topsin-M; o-Bis(3-methoxycarbonyl-2-thioureido)benzene; Topsin turf and ornamentals; BAS 32500F | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Fungal 3-ketosteroid reductase (erg27) | Target Info | |||||||||
| Gene Name | erg27 | ||||||||||
| Uniprot ID | K0H656_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MGLPPWETSESQTFALITGANSGLGFAIASRLIDEFLTSSDTPPTKHLILILCTRTPLKT RFTISRLRAHLRKLADYSEFATSHRAKAKSQGNVYRWQDTVARVHFLGVEVDLCDLKSVY ALTDRLVNGTVGSPDATTMDGLRLPDGSPGTATYSADVKQDRWALSQKEGSEGELRSWGW GLSGIRIPRLDVVVLNAGIGGWSGIDWPKAIWTVITDMTEAVTWPTYKLAEIGVITKPQL SSASSKQAKPSDDEAAQPLLDGESPEEPPLGATFCSNVFGHYVLAHELMPLLSRTASPSA TTSGRIIWVSSIEAQAQHFDEDDLQGLESRTPYESSKRLTDVLVLSRKLRAAGQASSSWF DCSDVRVENSKSEEEPAAKLIRPKMYVVQPGIFVSEIMPLNFVLVFIYRLISYLVRWMGS QWHTIKPYTAAVAPVWVALSPDDVLDNMDGAASKWGSATDASGKERVIRTEVPGWGWEGK TPKTIDTGERRKGRQRNAEPLTREAREDFEVLGVKCWTEMENLRKEWEGLLKVKK [Bot rytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Two-component osmosensing histidine-kinase (bos1) | Target Info | |||||||||
| Gene Name | bos1 | ||||||||||
| Uniprot ID | Q8X1E7_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MEDSTIAHTTAILQTLALSSIDLPLTNVYGNKGIRLPGADTAEKLALERELAALVSRVQR LEARAITVNNQTLPDTPNELGAPSAFADVLTGAPSRASKSTTSRQQLVNSLLAAREAPTG GERPPKFTKLSDEELEALREHVDHQSKQLDSQKSELAGVHAQLFEQKQRQEQALNVLEVE RVAALERELKKHQQANEAFQKALREIGEIVTAVARGDLSKKVQIHSVEMDPEITTFKRVI NTMMDQLQIFSSEVSRVAREVGTEGILGGQAKISGVDGTWKELTDNVNVMAQNLTDQVRE IASVTTAVAHGDLTQKIERPAQGEILQLQQTINTMVDQLRTFAAEVTRVARDVGTEGILG GQAEIEGVQGMWNTLIVNVNAMANNLTTQVRDIAIVTTAVAKGDLTQKVQAECKGEIKQL KETINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTT QVREIAKVTTAVARGDLTKKIEVEVQGEIASLKDTINTMVDRLSTFAFEVSKVAREVGTD GTLGGQAQVDNVEGKWKDLTENVNTMARNLTTQVRGISTVTQAIANGDMSQKIEVAAAGE ILILKETINNMVDRLSIFSNEVQRVAKDVGVDGKMGGQADVAGIGGRWKEITTDVNTMAN NLTTQVRAFGDITNAATDGDFTKLITVEASGEMDELKRKINQMVYNLRDSIQRNTLAREA AEFANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVHNLANSLLTII DDILDLSKIEANRMIMEEIPYTLRGTVFNALKTLAVKANEKFLDLTYRVDSSVPDHVVGD SFRLRQVILNLVGNAIKFTEHGEVSLTIQKAEQDHCAPNEYAVEFCVSDTGIGIQADKLN LIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMRGDVWVKSQYGKGSSFYFTCTVRLAT SDISFIQKQLKPYQGHNVLFIDKGQTGHGKEIITMLTQLGLVPVVVDSEQHTILLGNGRT KEKIASTYDVIVVDSIESARKLRSIDEFKYIPIVLLAPVIHVSLKSALDLGITSYMTTPC LTIDLGNGMIPALENRAAPSLADNTKSFDILLAEDNIVNQRLAVKILEKYHHVVTVVGNG QEALDAIKEKRYDVILMDVQMPIMGGFEATAKIREYERSLGTQRTPIIALTAHAMLGDRE KCIQAQMDEYLSKPLKQNHLIQTILKCATLGGALLEKGREVRQSANEESPNSQNGPRGTQ HPASSPTPAHMRPAIEPRAYTTTGPINHGSAESPSLVTADAEDPLARLLMRAHSS [Bot rytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Cytochrome b (cytb) | Target Info | |||||||||
| Gene Name | cytb | ||||||||||
| Uniprot ID | Q18ND9_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MRIFKSHPLLKLVNSYMIDSPQPSNLSYLWNFGSLLAVCLVIQIITGVTLAMHYNPSVLE AFNSVEHIMRDVNNGWLIRYLHSNTASAFFFIVYLHIGRGLYYGSYRAPRTLVWTIGVVI FILMIVTAFLGYVLPYGQMSLWGATVITNLMSAVPWIGQDIVEFLWGGFSVNNATLNRFF ALHFVLPFVLAALALMHLIALHDSAGSGNPLGISGNYDRLAFAPYFLFKDLITIFLFIII LSIFVFFMPNVLGDSDNYIMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMLSAI LILLAMPFTDLSRSRGIQFRPLSKIAFYIFIANFLILMVLGAKHVESPYIEFGQISTVIY FAHFLIIVPFISLLENSLVELAVLTKEKPSR [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb) | Target Info | |||||||||
| Gene Name | sdhb | ||||||||||
| Uniprot ID | Q3ZMH5_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MAALRTGARSARAIFAASRPAFRTQMRTMASVDSSVPESPTVSPSRPVESASKTSTVKEP AADSESLIKTFNIYRWNPDEPTSKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRR SCREGICGSCAMNIDGVNTLACLCRIPRDAKHETKIYPLPHTYVVKDIVPDLTQFYKQYK SIKPYLQHTDPAPEGKEYLQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAIL LQSYRWLADSRDQKKEERKAALDNSMSLYRCHTILNCSRTCPKGLNPGLAIAEIKKEMAF [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Tubulin beta chain (tubA) | Target Info | |||||||||
| Gene Name | tubA | ||||||||||
| Uniprot ID | TBB_BOTFU | ||||||||||
| Species | Botrytis cinerea | ||||||||||
| Reference Sequence |
MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYV PRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVV RREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVV EPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCL RFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMM AASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRG LKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDASISEGEEEYEEEVPIEGEE [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Independent Emergence of Resistance to Seven Chemical Classes of Fungicides in Botrytis cinerea.Phytopathology.2015 Apr;105(4):424-32. | ||||||||||
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