Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0R6CD | ||||||||||
| Drug Name | Insulin | ||||||||||
| Synonyms | BrioDurance; Insulin (agglomerated vesicle technology, diabetes), Cense Biosciences; Insulin (subcutaneous/nanoparticle/suspension/sustained release formulation, diabetes); Insulin (subcutaneous/nanoparticle/suspension/sustained release formulation, diabetes), Cense Biosciences | ||||||||||
| Company | Cense Biosciences Inc | ||||||||||
| Drug Resistance Mutations | |||||||||||
| Target Name | Peroxisome proliferator-activated receptor gamma (PPARG) | Target Info | |||||||||
| Gene Name | PPARG | ||||||||||
| Uniprot ID | PPARG_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETDMSLHPLLQEIYKDLY [Homo sapiens] |
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| Targeted Disease | Coronary heart disease; Donohue syndrome; Hyperglycemia; Lipodystrophy | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.Diabetes.2010 Nov;59(11):2890-7. | ||||||||||
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