Drug General Information |
Drug ID |
D0Y3MO
|
Drug Name |
Amikacin |
|
Synonyms |
Amicacin; Amikacina; Amikacine; Amikacinum; Amikavet; Amikin; Arikace; Briclin; Kaminax; Lukadin; Mikavir; AMIKACIN SULFATE; Amikacin Base; Amikacin Dihydrate; ANTIBIOTIC BB-K8; Amiglyde-V; Amikacin & Tumor Necrosis Factor; Amikacin (USP); Amikacina [INN-Spanish]; Amikacine [INN-French]; Amikacinum [INN-Latin]; Amikin(Disulfate); Antibiotic BB-K 8; BB-K 8; BB-K8; Amiglyde-V (TN); Amikacin (USP/INN); Amikacin [USAN:BAN:INN]; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-6))-N(sup 3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine; O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->6))-N(3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine; O-3-Amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1->4)]-1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide; (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide; 1-N-(L(-)-gamma-Amino-alpha-hydroxybutyryl)kanamycin A |
Drug Type |
Small molecular drug |
Therapeutic Class |
Antibiotics |
Company |
Abbott Laboratories |
Structure |
|
Drug Resistance Mutations |
Target Name |
Bacterial 16S/23S rRNA (cytidine-2'-O)-methyltransferase (TlyA) |
Target Info |
Gene Name |
tlyA |
Uniprot ID |
TLYA_MYCTU |
Species |
Mycobacterium tuberculosis |
Reference Sequence |
MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSER AWVSRGAHKLVGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAW SLRNDPRVVVLERTNARGLTPEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPL VKPQFEVGKGQVGPGGVVHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYF LWLRTQTDRALSAKGLEDAVHRAISEGP [Mycobacterium tuberculosis]
|
Targeted Disease |
Tuberculosis |
Drug Resistance Mutations |
Mutation info |
Missense: A67E |
[1] |
|
Mutation info |
Missense: A91E |
[1] |
|
Mutation info |
Missense: E238K |
[1] |
|
Mutation info |
Missense: F185L |
[1] |
|
Mutation info |
Missense: K69E |
[1] |
|
Mutation info |
Missense: L118P |
[1] |
|
Mutation info |
Missense: L150P |
[1] |
|
Mutation info |
Missense: N236K |
[1] |
|
Mutation info |
Missense: P183L |
[1] |
|
Mutation info |
Frameshift: Plus 103 |
[1] |
|
Mutation info |
Frameshift: Plus 132 |
[1] |
|
Mutation info |
Frameshift: Plus 133 |
[1] |
|
Mutation info |
Frameshift: Plus 159 |
[1] |
|
Mutation info |
Frameshift: Plus 195 |
[1] |
|
Mutation info |
Frameshift: Plus 218 |
[1] |
|
Mutation info |
Frameshift: Plus 224 |
[1] |
|
Mutation info |
Frameshift: Plus 253 |
[1] |
|
Mutation info |
Frameshift: Plus 73 |
[1] |
|
Mutation info |
Frameshift: Plus 8 |
[1] |
|
Mutation info |
Frameshift: Plus 9 |
[1] |
|
Mutation info |
Nonsense: Q184 STOP |
[1] |
|
Mutation info |
Nonsense: Q22 STOP |
[1] |
|
Mutation info |
Missense: R14W |
[1] |
|
Mutation info |
Nonsense: R18 STOP |
[1] |
|
Mutation info |
Nonsense: R3 STOP |
[1] |
|
Mutation info |
Missense: V128E |
[1] |
|
References |
REF 1 |
Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2005 Feb;49(2):571-7.
|