Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00CDF
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| Former ID |
DIB018851
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| Drug Name |
andarine
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| Synonyms |
GTX007; GTX-007
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C19H18F3N3O6
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| Canonical SMILES |
CC(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O
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| InChI |
1S/C19H18F3N3O6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28H,10H2,1-2H3,(H,23,26)(H,24,27)/t18-/m0/s1
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| InChIKey |
YVXVTLGIDOACBJ-SFHVURJKSA-N
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| CAS Number |
CAS 401900-40-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14783679, 16356819, 24127334, 44922700, 46518728, 50075683, 51091126, 77753267, 87325162, 87557517, 99436998, 99443894, 103354676, 109692985, 118843816, 121380285, 124757027, 125163831, 126671644, 131480700, 136340309, 136367327, 136368098, 137006451, 137275994, 142268276, 144115609, 151980501, 152258346, 152344170, 160647184, 160657742, 160968502, 162011824, 162037461, 164042433, 164827207, 170497626, 172650052, 172914177, 174529284, 177749786, 184819094, 188899523, 198981980, 223366179, 223556770, 223669590, 223704968, 228777798
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| ChEBI ID |
CHEBI:94760
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Androgen receptor messenger RNA (AR mRNA) | Target Info | Agonist | [1] |
| KEGG Pathway | Oocyte meiosis | |||
| Pathways in cancer | ||||
| Prostate cancer | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| AndrogenReceptor Signaling Pathway | ||||
| FSH Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Coregulation of Androgen receptor activity | ||||
| Regulation of Androgen receptor activity | ||||
| Nongenotropic Androgen signaling | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| FOXA1 transcription factor network | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Nuclear Receptor transcription pathway | |||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Integrated Pancreatic Cancer Pathway | ||||
| Prostate Cancer | ||||
| Integrated Breast Cancer Pathway | ||||
| Nuclear Receptors | ||||
| Androgen receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. J Med Chem. 2009 Jun 25;52(12):3597-617. | |||
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